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New treatment option for B-cell Non-Hodgkin Lymphoma
Official title A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
ClinicalTrials.gov ID: NCT07123454
What this study is testing
What is AZD4512?
AZD4512 is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for b-cell non-hodgkin lymphoma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a Phase I/II open-label, global multicenter study to evaluate the safety and efficacy of AZD4512 monotherapy or in combination with other anticancer agent(s), in participants with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (B-NHL).
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Eligible patients must be adults (≥18 years)
- Documented histologically confirmed diagnosis of B-cell non-Hodgkin lymphoma (B-NHL) as per World Health Organization (WHO) 2022 classification. In...
- Patients must have relapsed or refractory disease after at least two prior lines of systemic therapy and lack additional standard options with...
You likely can't join if
- Patients are excluded if they have a diagnosis of post-transplant lymphoproliferative disease, Richter's transformation, Burkitt's lymphoma, or...
- Other exclusions include allogeneic Hematopoietic stem cell transplantation (HSCT) within 180 days (unless stable without active (graft-versus-host...
- Females who are pregnant or breastfeeding are not eligible.
The study team makes the final eligibility decision.
Where it's taking place
- Irvine, California, United States
- Jacksonville, Florida, United States
- Rochester, Minnesota, United States
- New York, New York, United States
- Cleveland, Ohio, United States
- Myrtle Beach, South Carolina, United States
- Franklin, Tennessee, United States
- Melbourne, Australia
- Chengdu, China
- Guangzhou, China
- Bologna, Italy
- Milan, Italy
- Bunkyō City, Japan
- Kōtoku, Japan
- Seoul, South Korea
- Taichung, Taiwan
- Taipei, Taiwan
- London, United Kingdom
- Newcastle upon Tyne, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Irvine, California, United States; Jacksonville, Florida, United States; Rochester, Minnesota, United States; New York, New York, United States; Cleveland, Ohio, United States; Myrtle Beach, South Carolina, United States and 13 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.