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New treatment option for Bronchopulmonary Dysplasia (BPD)
Official title Metformin for Premature Infants With Bronchopulmonary Dysplasia
ClinicalTrials.gov ID: NCT07120971
What this study is testing
What is Metformin (open-label)?
Metformin (open-label) is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for bronchopulmonary dysplasia (bpd).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The overall objective of this study is to investigate the role of metformin in decreasing lung injury and promoting lung growth in premature infants. There are two phases to this pilot study.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 7 to 6
You may be able to join if
- Phase 0:
- Birth gestational age of \< 29 weeks AND
- Postnatal age between 8 and 22 weeks AND
- Diagnosed with BPD at 36 weeks postnatal age Phase 1:
- Birth gestational age of \< 29 weeks, AND
You likely can't join if
- Persistent hypoglycemia
- Lactic acidosis
- Feeding intolerance
- Renal or hepatic dysfunction
- Active infection
- Congenital anomalies that preclude feedings
See the full eligibility criteria
- Phase 0:
- Birth gestational age of \< 29 weeks AND
- Postnatal age between 8 and 22 weeks AND
- Diagnosed with BPD at 36 weeks postnatal age Phase 1:
- Birth gestational age of \< 29 weeks, AND
- Requiring mechanical ventilation or positive pressure support at 7 days postnatal age, AND
- Postnatal age between 7 and 30 days
- Persistent hypoglycemia
- Lactic acidosis
- Feeding intolerance
- Renal or hepatic dysfunction
- Active infection
- Congenital anomalies that preclude feedings
- Infants whose parents have chosen palliative care
The study team makes the final eligibility decision.
Where it's taking place
- Milwaukee, Wisconsin, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 7 days to 6 months. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Milwaukee, Wisconsin, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.