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New treatment option for Activity-Related Knee Discomfort
Official title NT-II™ Collagen for Joint Discomfort and Function
ClinicalTrials.gov ID: NCT07119645
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn whether a natural marine supplement called NT-II™ (Salmon Undenatured Type II Collagen) can help lower knee discomfort caused by physical activity in otherwise healthy adults. Many active people experience knee pain when performing daily movements like climbing stairs, walking long distances, or squatting, even if they do not have a medical diagnosis such as arthritis.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 65
You may be able to join if
- Adults aged 20 to 65 years.
- Self-reported, reproducible knee discomfort associated with any knee-loading activities for at least 3 months prior to screening.
- Discomfort must occur in at least one knee during a nominated aggravating activity at least twice per week and subside with rest.
- VAS rating of 30 mm to 75 mm during the past week for the nominated activity.
- No current diagnosis of structural joint disease (e.g., osteoarthritis).
You likely can't join if
- Persistent knee pain at rest or recent acute lower-limb trauma.
- Diagnosed structural or inflammatory joint disorders.
- Current or recent physiotherapy targeting knee pain (within 6 months).
- Allergy to fish or any study product ingredients.
- Scheduled lower-limb surgery during the study period.
- Other musculoskeletal disorders affecting ambulation.
See the full eligibility criteria
- Adults aged 20 to 65 years.
- Self-reported, reproducible knee discomfort associated with any knee-loading activities for at least 3 months prior to screening.
- Discomfort must occur in at least one knee during a nominated aggravating activity at least twice per week and subside with rest.
- VAS rating of 30 mm to 75 mm during the past week for the nominated activity.
- No current diagnosis of structural joint disease (e.g., osteoarthritis).
- Engages in physical activity involving knee-loading movements at least twice weekly for 20+ minutes.
- BMI between 20.0 and 32.5 kg/m².
- In good general health with no significant medical comorbidities.
- Able and willing to provide informed consent.
- Capable of completing study procedures remotely using mobile technology.
- Persistent knee pain at rest or recent acute lower-limb trauma.
- Diagnosed structural or inflammatory joint disorders.
- Current or recent physiotherapy targeting knee pain (within 6 months).
- Allergy to fish or any study product ingredients.
- Scheduled lower-limb surgery during the study period.
- Other musculoskeletal disorders affecting ambulation.
- Recent joint injections (within 3 months).
- Use of joint supplements in the past 3 months.
- Use of analgesics ≥3 days/week in the past 3 months.
- NSAIDs/acetaminophen use is permitted with restrictions:
- Not within 24 hours of blood sampling or VAS assessments.
- Must be documented.
- Chronic use of medications that affect musculoskeletal symptoms (e.g., muscle relaxants, gabapentinoids) unless infrequent (≤2x/week) and not within 24 hours of assessments.
- Regular use of PPIs (\>3x/week in past month).
- Systemic corticosteroids, immunosuppressants, or opioids within 4 weeks.
- Unstable weight or significant recent dietary changes.
- Significant medical conditions (e.g., cancer, hepatic/renal impairment, CVD, thyroid disease, diabetes).
- Neurological, cognitive, or psychiatric disorders affecting participation.
- Use of tobacco/nicotine or other substances.
- Diagnosed sleep disorders.
- Strict vegan diet or sedentary lifestyle.
- Inability to swallow capsules.
- Pregnant, breastfeeding, or planning pregnancy.
- Women of childbearing potential not using contraception.
- Participation in another treatment clinical trial.
The study team makes the final eligibility decision.
Where it's taking place
- San Francisco, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 20 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Francisco, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.