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New treatment option for Mechanical Ventilation
Official title Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients
ClinicalTrials.gov ID: NCT07114289
What this study is testing
- What it's testing
- This study aims to find out which method of spontaneous breathing trial (SBT) better helps overweight and obese ICU patients prepare for extubation, which is the removal of the breathing tube. The two methods being compared are pressure support ventilation (PSV) and the T-piece.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- 1\. Patients had undergone intubation and mechanical ventilation for more than 24 hours prior to the first spontaneous breathing trial. 2\. Adult...
- Stable vital signs: heart rate \< 140 beats/min, systolic blood pressure: 90-160 mmHg, and no use of vasopressors or use of minimal doses (\<0.2...
- Respiratory rate ≤ 35 breaths/min.
- Adequate oxygenation, defined as either SpO2 \> 90% with FiO2 ≤ 0.4, or PaO2/FiO2 \> 150 mmHg with positive end-expiratory pressure (PEEP) ≤ 8 cmH2O.
- Adequate cough strength (MIP \< -20 cmH2O).
You likely can't join if
- Patients with tracheostomy.
- Patients who had been admitted for traumatic brain injury.
- Patients who had preexisting peripheral neuromuscular disease (underlying myopathy or myasthenia gravis).
- Patients who had a do-not-reintubate order at the time of the initial spontaneous breathing trial were excluded
- Patients who have already undergone a first spontaneous breathing trial.
- Patients who had undergone extubation without an SBT
See the full eligibility criteria
- 1\. Patients had undergone intubation and mechanical ventilation for more than 24 hours prior to the first spontaneous breathing trial. 2\. Adult patients aged ≥ 18 years. 3. BMI ≥ 25 kg/m². 4. Meeting all the Inter...
- Stable vital signs: heart rate \< 140 beats/min, systolic blood pressure: 90-160 mmHg, and no use of vasopressors or use of minimal doses (\<0.2 µg/kg per min).
- Respiratory rate ≤ 35 breaths/min.
- Adequate oxygenation, defined as either SpO2 \> 90% with FiO2 ≤ 0.4, or PaO2/FiO2 \> 150 mmHg with positive end-expiratory pressure (PEEP) ≤ 8 cmH2O.
- Adequate cough strength (MIP \< -20 cmH2O).
- An awake state, defined as a score of Richmond Agitation-Sedation Scale between +1 and -2, or Glasgow Coma Scale \> 8.
- No continuous sedation. 5. Informed consent provided by the patient or their relatives.
- Patients with tracheostomy.
- Patients who had been admitted for traumatic brain injury.
- Patients who had preexisting peripheral neuromuscular disease (underlying myopathy or myasthenia gravis).
- Patients who had a do-not-reintubate order at the time of the initial spontaneous breathing trial were excluded
- Patients who have already undergone a first spontaneous breathing trial.
- Patients who had undergone extubation without an SBT
- Protected populations: pregnant or breastfeeding women, individuals under guardianship, or those under legal protection.
- Patients who refused to participate during the study.
The study team makes the final eligibility decision.
Where it's taking place
- Taipei, Taiwan
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Taipei, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.