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New treatment option for Postoperative Cognitive Dysfunction
Official title Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
ClinicalTrials.gov ID: NCT07113483
What this study is testing
What is Midazolam?
Midazolam is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for postoperative cognitive dysfunction.
Also referred to as Dormicum, Versed, Midazolam Hydrochloride.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia. We want to find out which medication provides better sedation during the procedure and which one affects early recovery of brain function after surgery.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- Adults aged 65 years or older.
- Scheduled for traumatic or non-traumatic orthopedic surgery under regional anesthesia.
- Able to provide informed consent or have a legally authorized representative provide consent.
You likely can't join if
- Patient refusal to participate.
- Mini-Cog score less than 3 (indicative of significant cognitive impairment).
- Severe hepatic or renal failure.
- Known allergy to benzodiazepines or propofol.
- History of benzodiazepine dependence.
The study team makes the final eligibility decision.
Where it's taking place
- Bucharest, Romania
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bucharest, Romania. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.