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Compares treatment options for Multiple Myeloma
Official title Evaluating Premedication Regimens (Methylprednisolone vs Dexamethasone-based) for the Prevention of Systemic and Injection Site Reactions to Motixafortide in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization, PARADE Trial
ClinicalTrials.gov ID: NCT07101445
What this study is testing
What is Acetaminophen?
Acetaminophen is an investigational medicine, given as an once-daily injection under the skin, being studied as a potential treatment for multiple myeloma.
Also referred to as Acetaminophen (APAP), Paracetamol.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This phase IV trial compares the effect of premedication regimens with methylprednisolone versus dexamethasone for the prevention of allergic reaction to motixafortide in patients with multiple myeloma (MM) undergoing stem cell mobilization. MM patients that receive an autologous stem cell transplantation (ASCT) have better outcomes.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients must be aged 18 years or older.
- Patient must understand and voluntarily signed an informed consent form.
- Patient must be willing and able to adhere to the study schedule and other protocol requirements.
- Histologically confirmed multiple myeloma prior to enrollment and randomization.
- Eligible for hematopoietic stem cell mobilization and autologous hematopoietic stem cell transplantation as per institutional guidelines.
You likely can't join if
- Previous history of autologous or allogeneic hematopoietic cell transplantation.
- History of hemoglobin SS disease or hemoglobin S trait precluding the patient's ability to use G-CSF.
- History of steroid-induced psychosis or encephalopathy requiring medical intervention.
- History of type I or II diabetes mellitus that is poorly controlled or with high glucose variability precluding safe administration of dexamethasone...
- History of serious systemic reaction to motixafortide.
See the full eligibility criteria
- Patients must be aged 18 years or older.
- Patient must understand and voluntarily signed an informed consent form.
- Patient must be willing and able to adhere to the study schedule and other protocol requirements.
- Histologically confirmed multiple myeloma prior to enrollment and randomization.
- Eligible for hematopoietic stem cell mobilization and autologous hematopoietic stem cell transplantation as per institutional guidelines.
- Females of reproductive potential must use effective contraception during treatment with motixafortide and for 8 days after the final dose.
- Previous history of autologous or allogeneic hematopoietic cell transplantation.
- History of hemoglobin SS disease or hemoglobin S trait precluding the patient's ability to use G-CSF.
- History of steroid-induced psychosis or encephalopathy requiring medical intervention.
- History of type I or II diabetes mellitus that is poorly controlled or with high glucose variability precluding safe administration of dexamethasone 12mg IV as premedication in the opinion of the investigator.
- History of serious systemic reaction to motixafortide.
The study team makes the final eligibility decision.
Where it's taking place
- Atlanta, Georgia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Atlanta, Georgia, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.