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New treatment option for Oral Lichen Planus
Official title Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus
ClinicalTrials.gov ID: NCT07100613
What this study is testing
What is Clobetasol Patch?
Clobetasol Patch is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for oral lichen planus.
Also referred to as Mucoadhesive Clobetasol Patch.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if a mucoadhesive patch containing clobetasol alone or in combination with resveratrol can reduce symptoms and improve quality of life in adults with Oral Lichen Planus (OLP). The main questions it aims to answer are: Does the patch reduce oral pain and burning sensations?
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults aged 18 years or older.
- Clinical suspicion of Oral Lichen Planus (OLP).
- Histological confirmation of OLP based on World Health Organization (WHO) criteria (presence of hyperkeratosis, acanthosis, basal cell degeneration...
- Absence of epithelial dysplasia.
- Ability to understand and sign informed consent.
You likely can't join if
- Previous diagnosis or treatment for OLP.
- Use of topical or systemic corticosteroids in the last 4 weeks.
- Use of medications known to cause lichenoid reactions.
- History of allergic reactions to dental materials (e.g., amalgam).
- Hematological disorders or immunodeficiencies.
- Pregnancy or breastfeeding.
See the full eligibility criteria
- Adults aged 18 years or older.
- Clinical suspicion of Oral Lichen Planus (OLP).
- Histological confirmation of OLP based on World Health Organization (WHO) criteria (presence of hyperkeratosis, acanthosis, basal cell degeneration, and a band-like lymphocytic infiltrate in the lamina propria).
- Absence of epithelial dysplasia.
- Ability to understand and sign informed consent.
- Previous diagnosis or treatment for OLP.
- Use of topical or systemic corticosteroids in the last 4 weeks.
- Use of medications known to cause lichenoid reactions.
- History of allergic reactions to dental materials (e.g., amalgam).
- Hematological disorders or immunodeficiencies.
- Pregnancy or breastfeeding.
- Current use of immunosuppressive therapies.
- Inability or unwillingness to comply with study procedures.
The study team makes the final eligibility decision.
Where it's taking place
- Palermo, Italy, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Palermo, Italy, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.