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New treatment option for Socket Preservation
Official title Hyaluronic Acid and Polynucleotides in Ridge Preservation
ClinicalTrials.gov ID: NCT07099846
What this study is testing
- What it's testing
- The aim of this study is to test the use of a bovine-derived bone graft combined with a polynucleotides-rich hyaluronic acid (PNHA) gel for the preservation of the bone after a tooth extraction (alveolar ridge preservation) and to test the performance of a fully-digital workflow to rehabilitate the site with a dental implant. 40 patients in need for a single tooth extraction will be recruited at Centro di Odontoiatria, Università di Parma and they will be randomly assigned to 2 groups: extraction and spontaneous healing or extraction and regeneration of the site with a bovine-derived bone graft combined with a PNHA gel.
- This is a blinded study.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 and older
You may be able to join if
- ≥25-year-old males and females;
- good systemic health (self-assessment);
- presence of an unrestorable/hopeless tooth with periodontal attachment and buccal bone preserved at least for 2/3rd of the root and not associated...
- full mouth bleeding and plaque scores ≤ 25%
You likely can't join if
- uncontrolled or untreated periodontal disease;
- history of local (head and neck) radiation therapy in the past 5 years;
- acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic...
- medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone...
- history of alcohol or drug abuse;
- smokers of ≥10 cigarettes a day;
See the full eligibility criteria
- ≥25-year-old males and females;
- good systemic health (self-assessment);
- presence of an unrestorable/hopeless tooth with periodontal attachment and buccal bone preserved at least for 2/3rd of the root and not associated with acute periapical pathology;
- full mouth bleeding and plaque scores ≤ 25%
- uncontrolled or untreated periodontal disease;
- history of local (head and neck) radiation therapy in the past 5 years;
- acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic lesion are eligible);
- medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone metabolism (e.g. rheumatoid arthritis, osteoporosis) or transmittable diseases...
- history of alcohol or drug abuse;
- smokers of ≥10 cigarettes a day;
- self-reported pregnancy or lactation.
The study team makes the final eligibility decision.
Where it's taking place
- Parma, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 25 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Parma, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.