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New treatment option for Transgenderism
Official title Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version
ClinicalTrials.gov ID: NCT07092527
What this study is testing
What is Testosterone Cypionate 50 milligrams per millileter (mg/mL) Injectable Solution?
Testosterone Cypionate 50 milligrams per millileter (mg/mL) Injectable Solution is an investigational medicine, given as an once-weekly, being studied as a potential treatment for transgenderism.
Also referred to as Testosterone Replacement Therapy.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35, women only. Healthy volunteers may be eligible.
You may be able to join if
- Transgender/Non-binary Group, Initiating Testosterone Group
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Aged 18-35
- Plan to initiate testosterone therapy
You likely can't join if
- Pregnant
- Incarcerated
- Known cognitive impairment or institutionalized
- Hemoglobin less than 11 gm/dl at screening evaluation
- Weight less than 110 pounds
- BMI \ 35
See the full eligibility criteria
- Transgender/Non-binary Group, Initiating Testosterone Group
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Aged 18-35
- Plan to initiate testosterone therapy
- History of regular menstrual cycles (every 24-35 days) at baseline, before beginning TRT Cisgender Female Group
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Aged 18-35
- Having regular menstrual cycles (every 24-35 days)
- Pregnant
- Incarcerated
- Known cognitive impairment or institutionalized
- Hemoglobin less than 11 gm/dl at screening evaluation
- Weight less than 110 pounds
- BMI \ 35
- Current endocrine disease- including untreated thyroid abnormalities, pituitary or adrenal disease, polycystic ovary syndrome, or androgen producing tumor
- Current or recent pregnancy within two months of study enrollment
- Current or recent breast feeding within two months of study enrollment
- Diabetes, or renal, liver, or heart disease
- History of oophorectomy or hysterectomy
- History of radiation or surgery involving brain structures and/or pelvis/pelvic organs
- Currently taking any medications that may affect their reproductive hormones, such as contraceptive medications, androgens, estrogens, progestins, gonadotropin-releasing hormone (GnRH) antagonists, insulinomimetics, and...
- History of prior testosterone therapy
The study team makes the final eligibility decision.
Where it's taking place
- San Diego, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 35 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Diego, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.