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Official title Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
ClinicalTrials.gov ID: NCT07085754
What this study is testing
- What it's testing
- This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Age 18-40 years, gender not limited
- Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications
- Cognitively normal (Mini-Mental State Examination (MMSE) score \> 28)
- Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)
- Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study
You likely can't join if
- Presence of day-night sleep reversal
- Shift work within the past 6 months
- Travel across time zones or experience of jet lag within the past three weeks
- Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL [or 8 g]...
- Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation
- Family history of early-onset dementia
See the full eligibility criteria
- Age 18-40 years, gender not limited
- Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications
- Cognitively normal (Mini-Mental State Examination (MMSE) score \> 28)
- Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)
- Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study
- Presence of day-night sleep reversal
- Shift work within the past 6 months
- Travel across time zones or experience of jet lag within the past three weeks
- Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL [or 8 g] of pure alcohol)
- Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation
- Family history of early-onset dementia
- Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50
- Female participants who are currently pregnant or breastfeeding
- Individuals who need to drive or operate vehicles or machinery during the study period
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.