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New treatment option for Cardiac Surgery
Official title Natriuresis-guided Depletion After Cardiac Surgery
ClinicalTrials.gov ID: NCT07077772
What this study is testing
What is Furosemide intravenous titration based on natriuresis?
Furosemide intravenous titration based on natriuresis is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for cardiac surgery.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patient (age \> 18 years)
- Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG)...
- Undergoing surgery with cardiopulmonary bypass (CPB)
- Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician
- Written and oral informed consent obtained
You likely can't join if
- Aortic arch repair requiring deep hypothermic circulatory arrest
- Active endocarditis
- Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)
- Failure to wean from CPB requiring mechanical circulatory support
- Chronic kidney disease with an estimated glomerular filtration rate (eGFR) \< 60 mL/min
- Chronic use of loop diuretics
See the full eligibility criteria
- Adult patient (age \> 18 years)
- Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures
- Undergoing surgery with cardiopulmonary bypass (CPB)
- Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician
- Written and oral informed consent obtained
- Covered by the French national health insurance (Sécurité Sociale)
- Aortic arch repair requiring deep hypothermic circulatory arrest
- Active endocarditis
- Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)
- Failure to wean from CPB requiring mechanical circulatory support
- Chronic kidney disease with an estimated glomerular filtration rate (eGFR) \< 60 mL/min
- Chronic use of loop diuretics
- Known allergy to furosemide
- Active postoperative bleeding and/or reoperation for bleeding
- Participation in another treatment study that may affect the primary outcome measure
- Patient deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curatorship)
The study team makes the final eligibility decision.
Where it's taking place
- Amiens, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amiens, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.