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New treatment option for Essential Tremor
Official title Proof of Concept Study on BP1.4979 Effect on Essential Tremor
ClinicalTrials.gov ID: NCT07074002
What this study is testing
What is BP1.4979?
BP1.4979 is an investigational medicine, given as an once-weekly pill taken by mouth, being studied as a potential treatment for essential tremor.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if drug BP1.4979 works to treat essential tremors in adults. It will also learn about the safety of drug BP1.4979.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Male or female ≥18-85 years old
- Confirmed diagnosis of ET, characterized by meeting the following criteria: (a) the presence of a bilateral upper limb action tremor that occurs in...
- ET characterized by a TETRAS-P score of at least 1.5 in either the forward posture, wing beating posture, or finger-to-nose movement of at least one...
- Female patient: post-menopausal woman having at least 12 months of natural amenorrhea without any alternative medical cause, or woman of childbearing...
You likely can't join if
- Severe tremor, defined as patient with ET characterized by a TETRAS-P score of ≥ 3 in either the forward posture, wing beating posture, or...
- Isolated head tremor not accompanied with tremor of any other body part
- Medical history or clinical evidence of any other conditions, whether medical, neurological, or psychiatric, that could potentially explain or...
- Patient who takes a medication which may induce tremor
- Direct or indirect injury or trauma to the nervous system within 3 months before the onset of tremor
- Concomitant treatment with more than three drugs to treat ET
See the full eligibility criteria
- Male or female ≥18-85 years old
- Confirmed diagnosis of ET, characterized by meeting the following criteria: (a) the presence of a bilateral upper limb action tremor that occurs in isolation; (b) a minimum duration of 3 years; and (c) the tremor may or...
- ET characterized by a TETRAS-P score of at least 1.5 in either the forward posture, wing beating posture, or finger-to-nose movement of at least one upper extremity
- Female patient: post-menopausal woman having at least 12 months of natural amenorrhea without any alternative medical cause, or woman of childbearing potential using a highly effective method of contraception for the...
- Severe tremor, defined as patient with ET characterized by a TETRAS-P score of ≥ 3 in either the forward posture, wing beating posture, or finger-to-nose movement of at least one upper extremity, or tremor of trunk
- Isolated head tremor not accompanied with tremor of any other body part
- Medical history or clinical evidence of any other conditions, whether medical, neurological, or psychiatric, that could potentially explain or contribute to the presence of tremors
- Patient who takes a medication which may induce tremor
- Direct or indirect injury or trauma to the nervous system within 3 months before the onset of tremor
- Concomitant treatment with more than three drugs to treat ET
- Any prior procedures for the treatment of ET such as deep brain stimulation, brain lesioning, or magnetic resonance (MR)-guided procedures, including MR-guided focused ultrasound
The study team makes the final eligibility decision.
Where it's taking place
- Amiens, France
- Besançon, France
- Bron, France
- Clermont-Ferrand, France
- Créteil, France
- Lille, France
- Marseille, France
- Nancy, France
- Nice, France
- Nîmes, France
- Poitiers, France
- Rennes, France
- Strasbourg, France
- Toulouse, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amiens, France; Besançon, France; Bron, France; Clermont-Ferrand, France; Créteil, France; Lille, France and 8 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.