BridgeMD
New treatment option for Adverse Childhood Experiences
Official title ACEs, SIRT1, and Premature Vascular Aging in Humans
ClinicalTrials.gov ID: NCT07073352
What this study is testing
- What it's testing
- Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of future cardiovascular disease (CVD) risk [1, 2]. Previous work from our lab (IRB 202010095) and others [3] demonstrates impaired VEF in young adults with prior exposure to ACEs even in the absence of clinical CVD risk factors.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 30. Healthy volunteers may be eligible.
You may be able to join if
- 18 - 30 years
- ACE score of 0 OR ≥4 (Aim 1); ACE score ≥4 (Aim 2)
You likely can't join if
- Resting arterial blood pressure \>140/90 mmHg
- BMI ≥30 kg/m2 and/or weight unstable (\>2.27 kg change) last 6 month
- Cardiovascular, metabolic, or pulmonary disease
- Cardiovascular or metabolic prescription drug use
- Vasoactive antidepressant drug use (SSRIs and clonidine)
- Currently pregnant or breastfeeding
See the full eligibility criteria
- 18 - 30 years
- ACE score of 0 OR ≥4 (Aim 1); ACE score ≥4 (Aim 2)
- Resting arterial blood pressure \>140/90 mmHg
- BMI ≥30 kg/m2 and/or weight unstable (\>2.27 kg change) last 6 month
- Cardiovascular, metabolic, or pulmonary disease
- Cardiovascular or metabolic prescription drug use
- Vasoactive antidepressant drug use (SSRIs and clonidine)
- Currently pregnant or breastfeeding
- Heavy alcohol consumption (AUDIT screening)
- Use of illicit drugs
- Current tobacco use
- Regular vigorous (\>6 MET s) aerobic exercise (\>4 bouts/week, \>30 min/bout)
- Dietary supplementation with antioxidants or habitual use of NSAIDs
The study team makes the final eligibility decision.
Where it's taking place
- Iowa City, Iowa, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 30 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Iowa City, Iowa, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.