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New treatment option for Refractory Chronic Cough
Official title Cough Management Wellness App for Refractory or Unexplained Chronic Cough
ClinicalTrials.gov ID: NCT07070895
What this study is testing
- What it's testing
- The goal of this single-cohort clinical trial is to learn whether a smartphone-based Cough Management (CM) program can reduce cough frequency and burden in adults (21-80 years) who have refractory or unexplained chronic cough.  The main questions it aims to answer are: Does four weeks of using the CM feature in the CoughPro app lower objective cough rate (coughs per hour) compared with each participant's one-week baseline?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 and older
You may be able to join if
- Age 21 or older.
- Currently suffering from a cough that started at least 8 weeks ago that is largely unproductive (i.e., at least 50% of the time the cough produces...
- Normal chest X-ray or chest CT scan at some point that was prescribed specifically for their cough.
- At least one physician visit for cough with standard-of-care therapy but inadequate symptom relief.
- Stability of treatment: willing to avoid new cough treatments during study or report changes if they occur.
You likely can't join if
- Recent upper respiratory infection (past 4 weeks).
- History of hemoptysis (coughing up blood) since onset of the current cough.
- Current smoker (incl. vaping) of any substance.
- ≥10 consecutive pack-years smoking history within \<10 years prior to screening.
- Diagnosed with a chronic lung condition (COPD, emphysema, lung cancer, IPF, chronic bronchitis, asthma). Note: Suspected asthma without confirmed...
- Current or past head/neck cancer.
See the full eligibility criteria
- Age 21 or older.
- Currently suffering from a cough that started at least 8 weeks ago that is largely unproductive (i.e., at least 50% of the time the cough produces zero mucus that needs to be spit out or swallowed).
- Normal chest X-ray or chest CT scan at some point that was prescribed specifically for their cough.
- At least one physician visit for cough with standard-of-care therapy but inadequate symptom relief.
- Stability of treatment: willing to avoid new cough treatments during study or report changes if they occur.
- Ability to comply: willing/able to wear the watch daily for the required duration of study and to complete all required questionnaires.
- Informed consent: understanding of the study procedures and agreement to comply with protocol.
- Recent upper respiratory infection (past 4 weeks).
- History of hemoptysis (coughing up blood) since onset of the current cough.
- Current smoker (incl. vaping) of any substance.
- ≥10 consecutive pack-years smoking history within \<10 years prior to screening.
- Diagnosed with a chronic lung condition (COPD, emphysema, lung cancer, IPF, chronic bronchitis, asthma). Note: Suspected asthma without confirmed diagnosis or benefit from asthma therapy is not an exclusion.
- Current or past head/neck cancer.
- Difficulty swallowing.
- On ACE inhibitors, such as Benzapril (Lotensin), Captopril (Capoten), Enalapril/Enalaprilat (Vasotec oral and injectable), Fosinopril (Monopril), Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril...
- Prior treatment for cough by a speech-language pathologist.
- Living with another individual with a frequent cough that would interfere with monitoring.
- Participation in any cough intervention study within 30 days or 5 half-lives of the intervention.
- Major scheduled surgery during the study period.
The study team makes the final eligibility decision.
Where it's taking place
- Wilmington, Delaware, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wilmington, Delaware, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.