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New treatment option for Overweight and Obese Adults
Official title Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction
ClinicalTrials.gov ID: NCT07065643
What this study is testing
- What it's testing
- Obesity increases the risk of type 2 diabetes, cardiovascular disease, and certain cancers, primarily due to elevated abdominal fat storage. With nearly two-thirds of the UK population living with overweight or obesity, there is an urgent necessity for evidence-based public health guidance to promote healthy weight.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Adults (aged over 18years) who are healthy but overweight/obese (BMI 27-45kg/m2) males and females as:
- 15 women (age 40 or less years)
- 15 men (age 40 or less years)
- 15 women (age 55-65 years) in menopause\ ; not taking Hormone Replacement Therapy (HRT)
- 15 men (age 55-65 years)
You likely can't join if
- Potential volunteers will be asked to fill in a health questionnaire at the screening visit to assess their suitability for the study. This...
- weight loss medication (e.g. GLP agonists), β-blockers, antihistamines, antipsychotics, benzodiazepines, barbiturates, melatonin, Ritalin, modafinil...
- Females who are planning to be pregnant, are pregnant or are breastfeeding
- Anyone with coeliac disease or gluten intolerance or food allergy
- Anyone with diagnosed T1 or T2 diabetes
- Anyone suffering from a psychiatric disorder or any type of substance abuse Other exclusion criteria
See the full eligibility criteria
- Adults (aged over 18years) who are healthy but overweight/obese (BMI 27-45kg/m2) males and females as:
- 15 women (age 40 or less years)
- 15 men (age 40 or less years)
- 15 women (age 55-65 years) in menopause\ ; not taking Hormone Replacement Therapy (HRT)
- 15 men (age 55-65 years)
- 15 women (age 55-65 years) in menopause; taking HRT\ \
- menopause definition is no menstrual period for 12 months \ \ HRT - women will have continuously taken oestrogen HRT for 24 months
- Potential volunteers will be asked to fill in a health questionnaire at the screening visit to assess their suitability for the study. This information will allow us to exclude participants. Medication exclusion...
- weight loss medication (e.g. GLP agonists), β-blockers, antihistamines, antipsychotics, benzodiazepines, barbiturates, melatonin, Ritalin, modafinil, soporifics, hypnotics, antiepileptic drugs, diabetes medication (e.g...
- Females who are planning to be pregnant, are pregnant or are breastfeeding
- Anyone with coeliac disease or gluten intolerance or food allergy
- Anyone with diagnosed T1 or T2 diabetes
- Anyone suffering from a psychiatric disorder or any type of substance abuse Other exclusion criteria
- Anyone following a vegetarian or vegan diet
- Anyone currently following a weight loss programme (that may be affecting lifestyle, physical activity \& diet) or undergone gastric band/reduction surgery; including GLP agonist (e.g. Semaglutide injection, Ozempic®).
- Anyone currently participating in another research study
- Anyone with unsuitable veins for blood sampling
- Anyone who is unable to fluently speak, read and understand English
- Anyone who is unable to comply to an alcohol-free diet for 6 weeks
- Anyone unable to give fully informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Aberdeen, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aberdeen, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.