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New treatment option for Thalassemia
Official title Effect of Exercise on Body Composition and Bone Health in Patients With Thalassemia
ClinicalTrials.gov ID: NCT07064941
What this study is testing
- What it's testing
- The goal of this clinical trial is to determine if a weight bearing exercise intervention can improve body composition and bone health in adolescents and adults with Thalassemia. The main questions it aims to answer are: Does participation in a 12-week weight bearing exercise intervention change total body lean mass and percentage body fat (as assessed by DXA) in adolescents and adults with Thalassemia?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 14 to 40
You may be able to join if
- Age: 14 - 40 years
- BMD Z-score at any skeletal site \< -1.0
- Diagnosed with thalassemia (any genotype, regardless of transfusion dependency)
- Vitamin D (25-Hydroxy) drawn within the previous 12 months \>20 ng/mL
- English speaking, able to consent
You likely can't join if
- Patients who self-identify as 'exercisers' e.g. routinely exercise for minimum of 45 min/day, 5x/week
- Pregnant (unable to conduct bone density measurements in pregnant females)
- Hypogonadal, must be on replacement sex hormone therapy for min of 6 months
- Cardiac T2\ by Magnetic Resonance Imaging of \<20 ms (e.g. evidence of cardiac iron overload)
- Recent long bone or vertebral fracture (within the last 6 months)
- Cognitive impairment limiting ability to understand instructions during orientation
See the full eligibility criteria
- Age: 14 - 40 years
- BMD Z-score at any skeletal site \< -1.0
- Diagnosed with thalassemia (any genotype, regardless of transfusion dependency)
- Vitamin D (25-Hydroxy) drawn within the previous 12 months \>20 ng/mL
- English speaking, able to consent
- Patients who self-identify as 'exercisers' e.g. routinely exercise for minimum of 45 min/day, 5x/week
- Pregnant (unable to conduct bone density measurements in pregnant females)
- Hypogonadal, must be on replacement sex hormone therapy for min of 6 months
- Cardiac T2\ by Magnetic Resonance Imaging of \<20 ms (e.g. evidence of cardiac iron overload)
- Recent long bone or vertebral fracture (within the last 6 months)
- Cognitive impairment limiting ability to understand instructions during orientation
- Other conditions known to influence bone health or body composition as determined by the investigator
- Patients at risk for cardiovascular disease yet have not received a routine cardiology assessment within the previous 12 months
- Bone medication (e.g. Zometa, Prolia, Forteo) use in previous 2 years
The study team makes the final eligibility decision.
Where it's taking place
- Oakland, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 14 years to 40 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Oakland, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.