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New treatment option for To Evaluate the Effectiveness of Intra-canal Nano-ketrolac as a...
Official title The Effect of Intra-Canal Ketorolac Application on Post-Endodontic Pain
ClinicalTrials.gov ID: NCT07064083
What this study is testing
What is intracanal nano-ketrolac?
intracanal nano-ketrolac is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for to evaluate the effectiveness of intra-canal nano-ketrolac as a medicament in reducing post-endodontic pain in patients undergoing root canal treatment.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- After obtaining informed consent, the procedure begins with the administration of local anesthesia to ensure patient comfort. A standard approach involves using 2% lidocaine with 1:100,000 epinephrine, delivered either via infiltration for maxillary teeth or mental nerve block for mandibular posterior teeth.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50. Healthy volunteers may be eligible.
You may be able to join if
- Patients aged 18-50 years.
- Patients who are diagnosed with necrotic pulp and chronic apical periodontitis in a single-rooted tooth.
- Patients who provide written informed consent.
- Patients with no systemic diseases affecting pain perception or wound healing.
You likely can't join if
- Patients with irreversible pulpitis or acute periapical abscess
- Patients with a history of NSAID or opioid use within 24 hours before treatment.
- Pregnant or lactating women.
- Patients who require more than two-visits root canal treatment due to anatomical or pathological factors.
The study team makes the final eligibility decision.
Where it's taking place
- Giza, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Giza, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.