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New treatment option for Kidney Tumors
Official title Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery
ClinicalTrials.gov ID: NCT07062952
What this study is testing
- What it's testing
- This clinical trial is an open-label, randomized controlled study designed to evaluate the efficacyand safety of salt substitutes in protecting renal function after kidney tumor surgery, aiming toprovide dietary renal protection strategies for postoperative kidney tumor patients. lt will alsoassess the feasibility of salt substitute intervention.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Participants must meet all of the following criteria:
- Voluntary participation with signed informed consent from both the primary participant and all cohabiting family members, with commitment to study...
- Age ≥18 years at enrollment (when signing informed consent), any gender;
- Diagnosed kidney tumor patients who underwent radical nephrectomy or partial nephrectomy (no restrictions on surgical approach);
- Preoperative eGFR \>60 ml/min/1.73m² (calculated by CKD-EPI equation);
You likely can't join if
- Participants will be excluded if they meet any of the following:
- Participant or cohabiting family members currently using potassium-sparing diuretics or potassium supplements, or prior use of salt substitutes;
- Post-discharge eGFR \<45 ml/min/1.73m² without significant fluctuation;
- Comorbid chronic kidney diseases (e.g., diabetic nephropathy, lupus nephritis);
- Preoperative history of urinary tract obstruction;
- Cohabiting family member(s) with CKD (eGFR \<45 ml/min/1.73m²);
See the full eligibility criteria
- Participants must meet all of the following criteria:
- Voluntary participation with signed informed consent from both the primary participant and all cohabiting family members, with commitment to study procedures and follow-up;
- Age ≥18 years at enrollment (when signing informed consent), any gender;
- Diagnosed kidney tumor patients who underwent radical nephrectomy or partial nephrectomy (no restrictions on surgical approach);
- Preoperative eGFR \>60 ml/min/1.73m² (calculated by CKD-EPI equation);
- Serum potassium \<4.8 mmol/L;
- Predominantly home-based dietary habits (\>90% meals prepared at home, assessed via self-report);
- Normal contralateral renal function at screening;
- Normal cardiopulmonary and hepatic function:
- Participants will be excluded if they meet any of the following:
- Participant or cohabiting family members currently using potassium-sparing diuretics or potassium supplements, or prior use of salt substitutes;
- Post-discharge eGFR \<45 ml/min/1.73m² without significant fluctuation;
- Comorbid chronic kidney diseases (e.g., diabetic nephropathy, lupus nephritis);
- Preoperative history of urinary tract obstruction;
- Cohabiting family member(s) with CKD (eGFR \<45 ml/min/1.73m²);
- Planned postoperative nephrotoxic medications (e.g., anti-neoplastic agents, immunotherapy);
- Uncontrolled diabetes (HbA1c ≥12%);
- Uncontrolled hypertension (seated SBP ≥180 mmHg or DBP ≥110 mmHg), symptomatic hypotension (SBP \<90 mmHg), or clinically evident hypovolemia;
- Preoperative proteinuria (≥1+ on dipstick);
- Severe cardiovascular disease (NYHA Class III-IV), gastrointestinal obstruction, or hyperkalemia history;
- BMI \ 30 kg/m²;
- Participation in another clinical trial ≤30 days before randomization or concurrently;
- Communication barriers or anticipated non-adherence;
- Structural/functional urological abnormalities (e.g., duplicated kidneys, polycystic kidneys, renal artery stenosis, stones, BPH) or indwelling catheters;
- Prior radiotherapy/ablation/surgery on the contralateral kidney;
- Life expectancy \<6 months (e.g., metastatic renal carcinoma).
The study team makes the final eligibility decision.
Where it's taking place
- Nanjing, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nanjing, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.