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New treatment option for Muscle Wasting
Official title The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
ClinicalTrials.gov ID: NCT07062562
What this study is testing
- What it's testing
- The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years). The main questions to answer are: Does whole-body NMES followed by protein intake improve muscle protein synthesis rates during 3 days of bed rest?
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35. Healthy volunteers may be eligible.
You may be able to join if
- Aged from 18-35 years
- 18.5 \< BMI \< 30 kg m2
- Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
You likely can't join if
- Employed or undertaking a thesis or internship at the department of Human and Animal Physiology at Wageningen University
- Smoking
- Diabetes (Type 1, Type 2, or genetic form of diabetes)
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- Known allergy to lidocaine
See the full eligibility criteria
- Aged from 18-35 years
- 18.5 \< BMI \< 30 kg m2
- Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
- Employed or undertaking a thesis or internship at the department of Human and Animal Physiology at Wageningen University
- Smoking
- Diabetes (Type 1, Type 2, or genetic form of diabetes)
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- Known allergy to lidocaine
- Prone to keloid forming (i.e. hyperplastic growth of scars)
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
- Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
- Currently involved in a structured progressive resistance training programme (\>3 times per week)
- A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia
- Any previous motor disorders or disorders in muscle and/or lipid metabolism
- Any back, leg, knee, neck, shoulder or postural complaints
- Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- Contra-indications for DXA scans (e.g. undergoing radiologic examination)
- Lactose intolerance
- Known severe kidney problems
- Pregnant or breastfeeding
- Unable to give consent
The study team makes the final eligibility decision.
Where it's taking place
- Wageningen, Gelderland, Netherlands
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 35 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wageningen, Gelderland, Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.