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New treatment option for Colectomy
Official title Perioperative Intravenous Nimodipine Trial
ClinicalTrials.gov ID: NCT07048522
What this study is testing
What is Nimodipine?
Nimodipine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for colectomy.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Patients scheduled for open surgical treatment of bowel cancer at the General Hospital of Patra
You likely can't join if
- Age \ 75 years
- American Society of Anesthesiologists (ASA) physical status \> III
- Allergy to nimodipine
- Inability to provide informed consent
- Known severe renal insufficiency
- Known severe bradyarrhythmia
See the full eligibility criteria
- Patients scheduled for open surgical treatment of bowel cancer at the General Hospital of Patra
- Age \ 75 years
- American Society of Anesthesiologists (ASA) physical status \> III
- Allergy to nimodipine
- Inability to provide informed consent
- Known severe renal insufficiency
- Known severe bradyarrhythmia
- Daily opioid consumption the last 7 days before surgery
- Pain intensity assessed using the Numerical Rating Scale (NRS; 0-10), with scores greater than 5 reported on more than half of the days during the past month.
The study team makes the final eligibility decision.
Where it's taking place
- Pátrai, Achaea, Greece
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pátrai, Achaea, Greece. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.