BridgeMD
New treatment option for Brown Adipose Tissue
Official title Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
ClinicalTrials.gov ID: NCT07048405
What this study is testing
- What it's testing
- This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health. While intermittent cold exposure has been shown to increase BAT activity and mass, as measured by fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) scans, the molecular adaptations within BAT and other thermogenic tissues including skeletal muscle and white adipose tissue (WAT) remain poorly understood.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Aged 18-40 years
- Body mass index 18.5-25 kg/m2
- Weight change of less than 5% in the past 6 months
- No acute or chronic medical conditions
- On no regular medications (other than contraceptives in female participants)
You likely can't join if
- Not meeting inclusion criteria
- Contra-indication to PET/CT scan
- Allergy to local anaesthetic
See the full eligibility criteria
- Aged 18-40 years
- Body mass index 18.5-25 kg/m2
- Weight change of less than 5% in the past 6 months
- No acute or chronic medical conditions
- On no regular medications (other than contraceptives in female participants)
- No claustrophobia
- Alcohol intake ≤14 units/ week
- Screening blood tests within acceptable limits (of no clinical significance)
- Not currently pregnant, lactating or breastfeeding (female participants only)
- Ability to provide informed consent.
- Not meeting inclusion criteria
- Contra-indication to PET/CT scan
- Allergy to local anaesthetic
The study team makes the final eligibility decision.
Where it's taking place
- Edinburgh, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Edinburgh, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.