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New treatment option for Alzheimer Disease
Official title Effects and Mechanisms of Temporal Interference Brain Stimulation on Memory Function in Preclinical Alzheimer's Disease
ClinicalTrials.gov ID: NCT07031687
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn if personalized, multimodal imaging-guided, EEG-based closed-loop Temporal Interference Brain Stimulation (TIBS) can improve memory function in individuals with preclinical Alzheimer's Disease (AD). The main questions it aims to answer are: 1.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 to 80
You may be able to join if
- Individuals recruited from neurology memory clinics or communities.
- Age between 60 and 80 years old, inclusive; no gender limitation.
- Right-handed.
- Cognitive function test results within normal range after age, gender, and education-level adjustment, OR mild cognitive impairment not yet meeting...
- Individuals classified as preclinical AD based on the revised 2024 AD diagnostic and staging criteria (i.e., cognitively normal with positive plasma...
You likely can't join if
- Past or present neurological diseases (e.g., stroke, epilepsy, Parkinson's disease, multiple sclerosis).
- Psychiatric disorders such as severe depression or severe anxiety.
- Systemic diseases causing cognitive decline (e.g., severe thyroid dysfunction, severe liver or kidney disease, severe nutritional deficiencies).
- Currently taking medications that may affect cognitive function (e.g., anticholinergics, benzodiazepines, antipsychotics) that cannot be discontinued...
- Other factors leading to cognitive decline that are not AD-related.
- Contraindications for MRI scans, such as claustrophobia, implanted metallic devices (e.g., pacemakers, cochlear implants, aneurysm clips), or history...
See the full eligibility criteria
- Individuals recruited from neurology memory clinics or communities.
- Age between 60 and 80 years old, inclusive; no gender limitation.
- Right-handed.
- Cognitive function test results within normal range after age, gender, and education-level adjustment, OR mild cognitive impairment not yet meeting diagnostic criteria for Mild Cognitive Impairment (MCI), OR only...
- Individuals classified as preclinical AD based on the revised 2024 AD diagnostic and staging criteria (i.e., cognitively normal with positive plasma p-tau217 or positive Aβ PET).
- Full understanding of the study, voluntary participation, and provision of written informed consent approved by the Ethics Committee.
- Past or present neurological diseases (e.g., stroke, epilepsy, Parkinson's disease, multiple sclerosis).
- Psychiatric disorders such as severe depression or severe anxiety.
- Systemic diseases causing cognitive decline (e.g., severe thyroid dysfunction, severe liver or kidney disease, severe nutritional deficiencies).
- Currently taking medications that may affect cognitive function (e.g., anticholinergics, benzodiazepines, antipsychotics) that cannot be discontinued or adjusted.
- Other factors leading to cognitive decline that are not AD-related.
- Contraindications for MRI scans, such as claustrophobia, implanted metallic devices (e.g., pacemakers, cochlear implants, aneurysm clips), or history of head injury with retained metal fragments.
The study team makes the final eligibility decision.
Where it's taking place
- Sanya, Hainan, China
- Beijing, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Sanya, Hainan, China; Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.