BridgeMD
New treatment option for CABG
Official title Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)
ClinicalTrials.gov ID: NCT07031128
What this study is testing
- What it's testing
- One of the most common major surgeries that older patients undergo is coronary artery bypass grafting surgery (CABG), which is performed in approximately 400,000 patients in the United States each year. CABG invokes a massive surgical stress response, with systemic epinephrine increasing 33-fold and norepinephrine increasing 3-fold.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older
You may be able to join if
- Scheduled for elective CABG with cardiopulmonary bypass
- Aged 50 years and above
- Adequate cognitive function to be able to give informed consent
You likely can't join if
- Patients already taking AKG as a supplement
- Substance abuse disorder either untreated or treated
- Post-traumatic stress disorder, bipolar disorder, Schizophrenia, or any other untreated or poorly controlled mental health or mood disorder, or...
- HIV/AIDS
- Patients undergoing or scheduled to undergo chemotherapy or any other treatment for malignancy
- Patients scheduled for immunosuppressant therapy for transplant
See the full eligibility criteria
- Scheduled for elective CABG with cardiopulmonary bypass
- Aged 50 years and above
- Adequate cognitive function to be able to give informed consent
- Patients already taking AKG as a supplement
- Substance abuse disorder either untreated or treated
- Post-traumatic stress disorder, bipolar disorder, Schizophrenia, or any other untreated or poorly controlled mental health or mood disorder, or history of hospitalization due to mental health condition in the past 3...
- HIV/AIDS
- Patients undergoing or scheduled to undergo chemotherapy or any other treatment for malignancy
- Patients scheduled for immunosuppressant therapy for transplant
- Patients with an active infection requiring antibiotic or antiviral therapy
- Pregnant women / planning to conceive / breastfeeding women
- Patients who are taking chronic anti-inflammatory drugs e.g., NSAIDS
- Patients who are hypersensitivity to AKG or placebo or any components of the respective tablets to be administered
The study team makes the final eligibility decision.
Where it's taking place
- Singapore, Singapore, Singapore
- Singapore, Singapore
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Singapore, Singapore, Singapore; Singapore, Singapore. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.