BridgeMD
New treatment option for Side-Effect
Official title pErsonalised Nocebo Assessment of Beta-blockEr Symptoms in Heart Failure
ClinicalTrials.gov ID: NCT07029906
What this study is testing
What is Bisoprolol 2.5 mg?
Bisoprolol 2.5 mg is an investigational medicine, given as an once-weekly pill taken by mouth, being studied as a potential treatment for side-effect.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Beta-blocker tablets are an effective treatment for heart failure that make people live longer and reduce the need to be admitted to hospital. Many patients who are at high risk of death are prescribed beta-blockers, but later choose to stop taking them because of symptoms that they perceive to be side-effects.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Heart failure with index LVEF \<40%
- Not currently taking beta-blocker tablets
- Previously tried one of beta-blocker tablet, and stopped taking it due to symptoms attributed to the beta-blocker
- Consenting to participate in the study
You likely can't join if
- Documented anaphylaxis to beta-blockers
- Clinical contraindication to Bisoprolol including (but not limited to):
- Asthma requiring BTS treatment step 3 or higher
- Marked bradycardia (\<50 bpm)
- Symptomatic hypotension (systolic BP \<85mmHg)
- Metabolic acidosis
See the full eligibility criteria
- Heart failure with index LVEF \<40%
- Not currently taking beta-blocker tablets
- Previously tried one of beta-blocker tablet, and stopped taking it due to symptoms attributed to the beta-blocker
- Consenting to participate in the study
- Documented anaphylaxis to beta-blockers
- Clinical contraindication to Bisoprolol including (but not limited to):
- Asthma requiring BTS treatment step 3 or higher
- Marked bradycardia (\<50 bpm)
- Symptomatic hypotension (systolic BP \<85mmHg)
- Metabolic acidosis
- Phaeochromocytoma
- 1st degree heart block with PR interval \>250ms
- 2nd degree or complete heart block
- Sick sinus syndrome
- Acute pulmonary oedema
- Life expectancy \<1 year
- Patient refusal or inability to participate in the study
The study team makes the final eligibility decision.
Where it's taking place
- London, United Kingdom
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.