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New treatment option for Myocardial Injury
Official title Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery
ClinicalTrials.gov ID: NCT07028593
What this study is testing
What is Propofol?
Propofol is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for myocardial injury.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Myocardial injury after noncardiac surgery (MINS) refers to postoperative elevation of cardiac troponin (cTn) levels caused by underlying ischemic mechanisms (i.e., coronary artery supply-demand imbalance or atherosclerotic thrombosis) without obvious non-ischemic causes (such as pulmonary embolism), with at least one cTn concentration exceeding the 99th percentile of the test reference upper limit, regardless of whether clinical symptoms and ECG changes are present. MINS, including myocardial infarction and ischemic myocardial injury, typically occurs within 30 days after surgery, most commonly within the first 2 postoperative days.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 80
You may be able to join if
- Scheduled for elective video-assisted thoracoscopic (VATS)-assisted thoracic surgery (lobectomy, segmentectomy, wedge resection of two or more lung...
- Aged 45 to 80 years (inclusive) at the time of randomization;
- Expected postoperative hospital stay of ≥3 days;
- Signed a written informed consent to participate in the study.
You likely can't join if
- Patients allergic to propofol, Ciprofol, or analogs of drug excipient components (soybeans, eggs, milk);
- Patients with unstable angina;
- Patients with congestive heart failure or hemodynamic instability requiring vasopressor agents;
- Patients with severe COPD (FEV1 \< 1 L);
- Glomerular filtration rate [eGFR] \< 30 mL/min/1.73m²;
- Patients with severe hepatic dysfunction (ALT or AST elevation exceeding 1.5 times the upper limit of normal);
See the full eligibility criteria
- Scheduled for elective video-assisted thoracoscopic (VATS)-assisted thoracic surgery (lobectomy, segmentectomy, wedge resection of two or more lung tissues, mediastinal tumor resection) under general anesthesia;
- Aged 45 to 80 years (inclusive) at the time of randomization;
- Expected postoperative hospital stay of ≥3 days;
- Signed a written informed consent to participate in the study.
- Patients allergic to propofol, Ciprofol, or analogs of drug excipient components (soybeans, eggs, milk);
- Patients with unstable angina;
- Patients with congestive heart failure or hemodynamic instability requiring vasopressor agents;
- Patients with severe COPD (FEV1 \< 1 L);
- Glomerular filtration rate [eGFR] \< 30 mL/min/1.73m²;
- Patients with severe hepatic dysfunction (ALT or AST elevation exceeding 1.5 times the upper limit of normal);
- Male or female patients planning to conceive within the next 3 months;
- Pregnant or lactating female patients;
The study team makes the final eligibility decision.
Where it's taking place
- Wuhan, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wuhan, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.