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New treatment option for Critical Illness Myopathy
Official title NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness
ClinicalTrials.gov ID: NCT07017517
What this study is testing
- What it's testing
- The goal of this clinical trial is to study whether physical therapy can reduce NLRP3 inflammasome activation and muscle atrophy in patients with critical illness myopathy (CIM). It will also explore the role of NLRP3 inflammasome in the pathophysiology of CIM.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Medical diagnosis of sepsis upon ICU admission.
- Receiving invasive mechanical ventilation with a projected requirement ≥7 days.
- SOFA score ≥8 for three consecutive days within the first five days of ICU admission.
You likely can't join if
- Neurocritical illness.
- Prior malnutrition or cachexia.
- Pre-existing neuromuscular disease.
- Coagulopathy (severe liver disease or continuous dialysis).
- Thrombocytopenia \<20,000 platelets/μL.
- Prior Clinical Frailty Scale ≥4.
See the full eligibility criteria
- Medical diagnosis of sepsis upon ICU admission.
- Receiving invasive mechanical ventilation with a projected requirement ≥7 days.
- SOFA score ≥8 for three consecutive days within the first five days of ICU admission.
- Neurocritical illness.
- Prior malnutrition or cachexia.
- Pre-existing neuromuscular disease.
- Coagulopathy (severe liver disease or continuous dialysis).
- Thrombocytopenia \<20,000 platelets/μL.
- Prior Clinical Frailty Scale ≥4.
- Lower limb amputation or fractures.
- Ongoing chemotherapy.
- Pregnancy.
- BMI \>35.
- Uncontrolled epilepsy.
- Allergy to ultrasound gel.
- Prior prolonged corticosteroid therapy.
- Expected ICU stay \<7 days.
- Imminent death.
- Legal guardian refusal to provide informed consent.
The study team makes the final eligibility decision.
Where it's taking place
- Santiago, Metropolitan Region, Chile
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Santiago, Metropolitan Region, Chile. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.