BridgeMD
New treatment option for Emotional Processing
Official title Combined Blood Pressure Medication and Activity Scheduling for Low Mood
ClinicalTrials.gov ID: NCT07017023
What this study is testing
What is Losartan with BA?
Losartan with BA is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for emotional processing.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study explores the effects of 7-day losartan (50mg) versus placebo with brief behavioural activation on emotional processing in young volunteers low in positive mood
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Willing and able to provide informed consent
- Aged 18-65 years
- Self-reported low levels of positive mood
- Sufficient written and spoken English skills to understand study procedures
- Normal or corrected to normal vision and hearing
You likely can't join if
- Antidepressant treatment or medication in last three months
- Currently receiving cognitive-behavioural therapy with behavioural activation
- History of psychosis or bipolar disorder
- History of substance dependence
- Use of illegal drugs in last 3 months
- First-degree relative with history of psychosis or bipolar disorder
See the full eligibility criteria
- Willing and able to provide informed consent
- Aged 18-65 years
- Self-reported low levels of positive mood
- Sufficient written and spoken English skills to understand study procedures
- Normal or corrected to normal vision and hearing
- Access to a computer and reliable internet connection
- Antidepressant treatment or medication in last three months
- Currently receiving cognitive-behavioural therapy with behavioural activation
- History of psychosis or bipolar disorder
- History of substance dependence
- Use of illegal drugs in last 3 months
- First-degree relative with history of psychosis or bipolar disorder
- Current or past hospitalisation for mental health reasons
- BDI-II score \>30
- Judged to be currently at clinical risk of suicide
- Past suicide attempt
- CNS-medication last 6 weeks (including in another study)
- Severely underweight or overweight in a manner that renders them unsuitable for the study in the opinion of the study medic
- Current blood pressure or other heart medication
- Diagnosis of intravascular fluid depletion or dehydration
- History of angioedema
- Impaired kidney function (based on self-report)
- Very low blood pressure following established definitions (at least three consecutive measurements of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are...
- Current diagnosis of a developmental disorder (e.g. ADHD, Tourette's syndrome, severe learning disability) according to self-report, where in the opinion of the study team such difficulties would likely interfere with...
- Current diagnosis of a neurological disorder (e.g. epilepsy, MS) according to self-report
- Lifetime history of systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the...
- Pregnancy (urine pregnancy test during Baseline Visit), breast feeding or plans to become pregnant during study participation
- Heavy use of cigarettes (smoke \> 20 cigarettes per day)
- Severe lactose intolerance (due to losartan containing some lactose monohydrate)
The study team makes the final eligibility decision.
Where it's taking place
- Oxford, Oxfordshire, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Oxford, Oxfordshire, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.