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Compares treatment options for Knee Osteoarthritis
Official title Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis
ClinicalTrials.gov ID: NCT07016672
What this study is testing
- What it's testing
- Gonarthrosis is a chronic pathology affecting the knee joint and tissues. It is characterized by progressive degeneration of articular cartilage, bone and surrounding structures.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years ;
- MRI confirmed grade III or IV unilateral gonarthrosis ;
- Pain ≥ 3/10 on the visual analogue scale (VAS);
- Patient with a BMI \< 35
- Patient capable of giving consent prior to participation in the study;
You likely can't join if
- Non-steroidal anti-inflammatory drugs\ or corticosteroids\ \ taken in the 7 days prior to inclusion;
- Local injection of hyaluronic acid in the 2 months prior to inclusion;
- Local injection of PRP within 1 year prior to inclusion;
- Local injection of corticosteroids within 5 months prior to inclusion;
- Current anticoagulant treatment that cannot be stopped during the hyaluronic acid or PRP injection protocol period;
- Patient diagnosed with any type of cancer in the last 3 years;
See the full eligibility criteria
- Age ≥ 18 years ;
- MRI confirmed grade III or IV unilateral gonarthrosis ;
- Pain ≥ 3/10 on the visual analogue scale (VAS);
- Patient with a BMI \< 35
- Patient capable of giving consent prior to participation in the study;
- Affiliated or entitled under a social security scheme.
- Non-steroidal anti-inflammatory drugs\ or corticosteroids\ \ taken in the 7 days prior to inclusion;
- Local injection of hyaluronic acid in the 2 months prior to inclusion;
- Local injection of PRP within 1 year prior to inclusion;
- Local injection of corticosteroids within 5 months prior to inclusion;
- Current anticoagulant treatment that cannot be stopped during the hyaluronic acid or PRP injection protocol period;
- Patient diagnosed with any type of cancer in the last 3 years;
- Pregnant women, women in labour or breast-feeding women;
- Patients under judicial protection (guardianship, curatorship, etc.) or safeguard of justice;
- Any other reason which, in the opinion of the investigator, could interfere with the evaluation of the study objectives.
- Acetylsalicylic acid is allowed when it is prescribed as an antiplatelet agent at doses lower than or equal to 160 mg per day. It has, indeed, no anti-inflammatory effect at these doses.
- Corticosteroids can be administered when they have a local action different from the one applied to the treated knee (cutaneous, instiled or inhaled routes).
The study team makes the final eligibility decision.
Where it's taking place
- Toulon, Var, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toulon, Var, France. Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.