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Compares treatment options for Venous Thromboembolism (VTE)
Official title REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
ClinicalTrials.gov ID: NCT07015905
What this study is testing
What is REGN7508?
REGN7508 is an investigational medicine, being studied as a potential treatment for venous thromboembolism (vte).
Also referred to as cenvacibart.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Is undergoing a primary elective unilateral TKA
- Is in good health based on laboratory safety testing as described in the protocol
- Body weight ≤130 kg at screening visit as described in the protocol Key
You likely can't join if
- Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study...
- History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion as described in the protocol
- History of thromboembolic disease or thrombophilia
- History of major surgery, including brain, spinal, or ocular, or major trauma within approximately the past 6 months prior to randomization
- Has an estimated Glomerular Filtration Rate (GFR) of \<30 mL/min/1.73 m2 at the screening visit as described in the protocol Note: Other...
The study team makes the final eligibility decision.
Where it's taking place
- Sheffield, Alabama, United States
- Riverside, California, United States
- Englewood, Colorado, United States
- Delray Beach, Florida, United States
- Miami, Florida, United States
- Pensacola, Florida, United States
- Sarasota, Florida, United States
- Tamarac, Florida, United States
- Baltimore, Maryland, United States
- Boston, Massachusetts, United States
- Westwood, New Jersey, United States
- Durham, North Carolina, United States
- Plymouth Meeting, Pennsylvania, United States
- Bellaire, Texas, United States
- Dallas, Texas, United States
- Houston, Texas, United States
- McAllen, Texas, United States
- San Antonio, Texas, United States
- St. George, Utah, United States
- Pleven, Bulgaria
+ 21 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Sheffield, Alabama, United States; Riverside, California, United States; Englewood, Colorado, United States; Delray Beach, Florida, United States; Miami, Florida, United States; Pensacola, Florida, United States and 35 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.