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New treatment option for Acute Heart Failure
Official title The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure
ClinicalTrials.gov ID: NCT07008365
What this study is testing
What is Furosemide 20 Milligrams?
Furosemide 20 Milligrams is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for acute heart failure.
Also referred to as furosemide 500 milligrams, hydrochlorothiazide 25 milligrams.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Systemic venous congestion is the primary therapeutic target of intravenous loop diuretics in patients admitted for acute heart failure (AHF). Despite their utility, a significant proportion of AHF patients are discharged with persistent clinical symptoms of congestion (residual congestion).
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100
You may be able to join if
- Men or women over 18 years of age.
- Diagnosis of heart failure (HF) based on the latest HF guidelines published in 2022.
- N-terminal pro b-type natriuretic peptide (NT-proBNP) \> 1000 pg/mL or Brain Natriuretic Peptide (BNP) \> 250 pg/mL.
- Placement of a urinary catheter to allow for the measurement of intra-abdominal pressure.
- Intravascular or mixed congestion pattern, defined as the presence of one or more clinical signs of congestion (edema, ascites, and/or pleural...
You likely can't join if
- Patient with a stay in the Internal Medicine department \> 24 hours.
- Absence of sufficient clinical congestion (ADVOR score = 0 at the time of randomization).
- Patient\'s refusal to participate in the clinical trial.
- Inability or contraindication for urinary catheter placement.
- Systolic blood pressure at admission \< 100 mmHg.
- Heart rate at admission \> 170 beats per minute (bpm).
See the full eligibility criteria
- Men or women over 18 years of age.
- Diagnosis of heart failure (HF) based on the latest HF guidelines published in 2022.
- N-terminal pro b-type natriuretic peptide (NT-proBNP) \> 1000 pg/mL or Brain Natriuretic Peptide (BNP) \> 250 pg/mL.
- Placement of a urinary catheter to allow for the measurement of intra-abdominal pressure.
- Intravascular or mixed congestion pattern, defined as the presence of one or more clinical signs of congestion (edema, ascites, and/or pleural effusion).
- Signed informed consent
- Patient with a stay in the Internal Medicine department \> 24 hours.
- Absence of sufficient clinical congestion (ADVOR score = 0 at the time of randomization).
- Patient\'s refusal to participate in the clinical trial.
- Inability or contraindication for urinary catheter placement.
- Systolic blood pressure at admission \< 100 mmHg.
- Heart rate at admission \> 170 beats per minute (bpm).
- Cardiogenic shock.
- Acute myocardial ischemia.
- Patients receiving renal replacement therapy (ultrafiltration or peritoneal dialysis).
- Kidney transplant recipients.
- Serum hemoglobin \< 9 g/dL.
- Pregnancy or breastfeeding.
- History of hypersensitivity to hydrochlorothiazide or furosemide.
- Patients admitted from the Intensive Care Unit.
- Patients with recent cardiac surgery (within the last year) or heart transplant recipients.
- Need for inotropic support to maintain adequate cardiac and/or renal output.
The study team makes the final eligibility decision.
Where it's taking place
- Zaragoza, Spain
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Zaragoza, Spain. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.