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New treatment option for Hip Fractures
Official title Effects of Esketamine Combined With Dexmedetomidine on Postoperative Sleep Quality
ClinicalTrials.gov ID: NCT07002723
What this study is testing
What is Esketamine combined with dexmedetomidine?
Esketamine combined with dexmedetomidine is an investigational medicine, being studied as a potential treatment for hip fractures.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- 1. Eligible patients are randomly divided into experimental and control groups； 2.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- Age≥ 65 years old;
- Hip fracture surgery under neuraxial anesthesia;
- Signed informed consent.
You likely can't join if
- ASA classification≥ Class V;
- Presence of neuraxial anesthesia contraindications: coagulation dysfunction, thrombocytopenia, neuraxial mass, puncture site infection, etc.;
- Patients with contraindications to esketamine (such as allergies, intracranial aneurysms, hyperthyroidism and glaucoma);
- Patients with contraindications to dexmedetomidine (allergies);
- Patients with severe cardiovascular diseases such as sick sinus syndrome, severe sinus bradycardia (heart rate \< 50 beats/min), atrioventricular...
- Obstructive sleep apnea syndrome (STOP-BANG score \> 3 points);
See the full eligibility criteria
- Age≥ 65 years old;
- Hip fracture surgery under neuraxial anesthesia;
- Signed informed consent.
- ASA classification≥ Class V;
- Presence of neuraxial anesthesia contraindications: coagulation dysfunction, thrombocytopenia, neuraxial mass, puncture site infection, etc.;
- Patients with contraindications to esketamine (such as allergies, intracranial aneurysms, hyperthyroidism and glaucoma);
- Patients with contraindications to dexmedetomidine (allergies);
- Patients with severe cardiovascular diseases such as sick sinus syndrome, severe sinus bradycardia (heart rate \< 50 beats/min), atrioventricular block grade II or above without pacemaker, unstable angina, severe...
- Obstructive sleep apnea syndrome (STOP-BANG score \> 3 points);
- Patients with severe hepatic and renal insufficiency (such as Child-Pugh score III, creatinine clearance \< 35 mL/min, preoperative dialysis);
- Those who have delirium, dementia, moderate to severe cognitive dysfunction and psychiatric disorders before the start of the trial and are unable to communicate and cooperate with the investigator.
The study team makes the final eligibility decision.
Where it's taking place
- Shenzhen, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shenzhen, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.