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New treatment option for Epistaxis Nosebleed
Official title Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
ClinicalTrials.gov ID: NCT06997796
What this study is testing
What is Tranexamic Acid?
Tranexamic Acid is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for epistaxis nosebleed.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called cauterization) or insert pledgets (called nasal packing) into the nose to apply direct pressure to the bleeding site.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Capable of giving informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Adults 18 years or older
- Male or female
- Presenting to the ED with active, spontaneous epistaxis. Anterior versus posterior epistaxis will be identified a priori. Anterior epistaxis is...
You likely can't join if
- Prior sinonasal surgery within the preceding 1 month.
- Patients who required medical treatment for epistaxis in the preceding 30 days.
- Septum perforation.
- Known history of bleeding disorders, including thrombocytopenia, hemophilia, hereditary hemorrhagic telangiectasia, or von Willebrand disease.
- History of known thromboembolic disease, including subarachnoid hemorrhage, stroke, or TIA.
- Known history of disease of the central nervous system, including seizures, convulsions, or intra-cerebral disease processes/lesions.
See the full eligibility criteria
- Capable of giving informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Adults 18 years or older
- Male or female
- Presenting to the ED with active, spontaneous epistaxis. Anterior versus posterior epistaxis will be identified a priori. Anterior epistaxis is operationally defined as active nasal bleeding that occurs anterior to the...
- Prior sinonasal surgery within the preceding 1 month.
- Patients who required medical treatment for epistaxis in the preceding 30 days.
- Septum perforation.
- Known history of bleeding disorders, including thrombocytopenia, hemophilia, hereditary hemorrhagic telangiectasia, or von Willebrand disease.
- History of known thromboembolic disease, including subarachnoid hemorrhage, stroke, or TIA.
- Known history of disease of the central nervous system, including seizures, convulsions, or intra-cerebral disease processes/lesions.
- Known or suspected history of significant skull base trauma, including skull base fracture or cerebrospinal fluid leak.
- Known history of acquired disturbances of colour vision.
- Known hematuria or any bleeding related to the kidney.
- Pregnant and/or lactating women.
- History of known allergy or sensitivity to the study medication.
- Presence of signs or symptoms of concomitant emergent conditions, including myocardial infarction, stroke, major trauma, shock, or hemodynamic instability.
- Patients with other medical conditions including cognitive limitations or impairment due to substance abuse.
- Patients with any other condition that, in the opinion of the investigator, may present an unreasonable risk to the patient, may make the patient unreliable, or may interfere with the study assessments.
- Current participation in another treatment clinical trial.
The study team makes the final eligibility decision.
Where it's taking place
- Peterborough, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Peterborough, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.