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Tests treatment safety and results for Cholecystectomy
Official title Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
ClinicalTrials.gov ID: NCT06996561
What this study is testing
What is Nalbuphine Injection?
Nalbuphine Injection is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for cholecystectomy.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this study is to identify the genes as well as their association with Nalbuphine. This will help the investigator to identify opioid vulnerability in Pakistani population in the postoperative patients and will contribute to overcoming the opioid crisis, resulting in better and safer outcomes.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- All adult men or women
- Age 18 to 70 years
- ASA criteria 1,2 and 3
- Abdomino-pelvic surgeries (open hernia repair, appendicectomy, open cholecystectomy, laparotomy, hysterectomy, cystectomy) lasting 2-4 hours
You likely can't join if
- Surgical procedure duration lasting more than 4 hours
- Patients taking anti fungal fluconazole, anticoagulant (Warfarin or Clopidogrel) SNRI (Amitryptalline), Rifampicin or Buprenorphine,
- History of hypersensitivity or allergy to opioids,
- Pregnant or breastfeeding mothers,
- History of narcotic dependency, addiction, and withdrawal
- Patients experiencing any adverse side effects or complications during surgical procedure requiring intensive care admission
See the full eligibility criteria
- All adult men or women
- Age 18 to 70 years
- ASA criteria 1,2 and 3
- Abdomino-pelvic surgeries (open hernia repair, appendicectomy, open cholecystectomy, laparotomy, hysterectomy, cystectomy) lasting 2-4 hours
- Surgical procedure duration lasting more than 4 hours
- Patients taking anti fungal fluconazole, anticoagulant (Warfarin or Clopidogrel) SNRI (Amitryptalline), Rifampicin or Buprenorphine,
- History of hypersensitivity or allergy to opioids,
- Pregnant or breastfeeding mothers,
- History of narcotic dependency, addiction, and withdrawal
- Patients experiencing any adverse side effects or complications during surgical procedure requiring intensive care admission
- Refusing to participate in the study
- Surgical procedures utilizing other modes of intraoperative analgesia e.g epidural analgesia or nerve blocks
The study team makes the final eligibility decision.
Where it's taking place
- Karachi, Sindh, Pakistan
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Karachi, Sindh, Pakistan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.