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New treatment option for Heart Failure
Official title A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
ClinicalTrials.gov ID: NCT06991257
What this study is testing
What is Low Dose PF-07328948?
Low Dose PF-07328948 is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for heart failure.
Also referred to as low dose.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).
- Phase 2: a mid-size study of how well it works
- Time commitment: about 48 weeks
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 79
You may be able to join if
- This study is seeking participants who are: Key include:
- aged 18 years to \< 80 years
- clinically confirmed to have a diagnosis of heart failure for at least 3 months
- New York Heart Association Class II-IV symptoms
- left ventricular ejection fraction greater than 40%
You likely can't join if
- include:
- Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
- Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
- History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
- Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
See the full eligibility criteria
- This study is seeking participants who are: Key include:
- aged 18 years to \< 80 years
- clinically confirmed to have a diagnosis of heart failure for at least 3 months
- New York Heart Association Class II-IV symptoms
- left ventricular ejection fraction greater than 40%
- Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
- Six-minute walking distance greater than 75 meters Key
- include:
- Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
- Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
- History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
- Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
The study team makes the final eligibility decision.
Where it's taking place
- Beverly Hills, California, United States
- Lake Forest, California, United States
- Santa Maria, California, United States
- Boca Raton, Florida, United States
- Jacksonville, Florida, United States
- Miami, Florida, United States
- North Miami Beach, Florida, United States
- Winter Park, Florida, United States
- Chicago, Illinois, United States
- Evanston, Illinois, United States
- Hazel Crest, Illinois, United States
- Fort Wayne, Indiana, United States
- Richmond, Indiana, United States
- Baltimore, Maryland, United States
- Bowie, Maryland, United States
- Lincoln, Nebraska, United States
- Lima, Ohio, United States
- Brownsville, Texas, United States
- McKinney, Texas, United States
- Tomball, Texas, United States
+ 96 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 48 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 79 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beverly Hills, California, United States; Lake Forest, California, United States; Santa Maria, California, United States; Boca Raton, Florida, United States; Jacksonville, Florida, United States; Miami, Florida, United States and 110 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.