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New treatment option for Spinal Cord Injury
Official title MEP Up-conditioning to Target Corticospinal Plasticity
ClinicalTrials.gov ID: NCT06989905
What this study is testing
- What it's testing
- Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand.
- Phase 1: an early, usually small safety study
- Time commitment: about 10 weeks
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult (≥18 yrs old)
- A history of injury to spinal cord at or above C6
- \>6 months post SCI
- Weak wrist extension at least unilaterally
- Expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g...
You likely can't join if
- Motoneuron injury
- Medically unstable condition
- Cognitive impairment
- A history of epileptic seizures
- Metal implants in the cranium
- Implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)
See the full eligibility criteria
- Adult (≥18 yrs old)
- A history of injury to spinal cord at or above C6
- \>6 months post SCI
- Weak wrist extension at least unilaterally
- Expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted.
- Motoneuron injury
- Medically unstable condition
- Cognitive impairment
- A history of epileptic seizures
- Metal implants in the cranium
- Implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)
- Extensive use of functional electrical stimulation to the arm on a daily basis
- Pregnancy (due to changes in posture and potential medical instability)
- Contraindications to MRI
- No measurable MEP elicited in the ECR
- Unable to produce any voluntary ECR EMG activity
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 10 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.