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New treatment option for Parkinson's Disease (PD)
Official title Accelerated TMS for Freezing of Gait in Parkinson's Disease
ClinicalTrials.gov ID: NCT06982638
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn whether a personalized brain stimulation method called repetitive transcranial magnetic stimulation (rTMS), combined with walking exercises, is a practical and tolerable approach to help people with Parkinson's disease who experience freezing of gait (FOG). FOG is a disabling symptom where people temporarily feel stuck and unable to start walking, even though they want to move.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80
You may be able to join if
- 50-80 years of age
- diagnosis of PD based on UK Brain Bank diagnostic criteria 55
- presence of FOG defined as a score of 1 on part 1 of the nFOGQ in which a video showing different types of freezing is played for the patient, a...
- no dopaminergic medication changes in the month prior
- observed FOG rated as \>1 in item 3.11 of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
You likely can't join if
- a history of other significant gait impairment unrelated to PD (e.g. orthopedic deformities)
- inability to complete gait assessments (timed up and go task) without assistance or assist devices
- barriers to making contact between the TMS coil and the skin (e.g. braids that cannot be removed)
- failing to meet all criteria on a standardized MRI/TMS safety screening: This includes, but is not limited to, the presence of claustrophobia...
- individuals with a diagnosis of psychosis or any other cognitive impairments that would make them unable to understand and follow study instructions...
- pregnancy
See the full eligibility criteria
- 50-80 years of age
- diagnosis of PD based on UK Brain Bank diagnostic criteria 55
- presence of FOG defined as a score of 1 on part 1 of the nFOGQ in which a video showing different types of freezing is played for the patient, a score of 1 represents a positive response of having experienced such an...
- no dopaminergic medication changes in the month prior
- observed FOG rated as \>1 in item 3.11 of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
- a history of other significant gait impairment unrelated to PD (e.g. orthopedic deformities)
- inability to complete gait assessments (timed up and go task) without assistance or assist devices
- barriers to making contact between the TMS coil and the skin (e.g. braids that cannot be removed)
- failing to meet all criteria on a standardized MRI/TMS safety screening: This includes, but is not limited to, the presence of claustrophobia, implanted electronic devices (e.g., pacemakers), metallic objects or...
- individuals with a diagnosis of psychosis or any other cognitive impairments that would make them unable to understand and follow study instructions or to consent for themselves.
- pregnancy
- individuals with a history of seizure
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.