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New treatment option for Brown Adipose Tissue (BAT) Physiology
Official title Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
ClinicalTrials.gov ID: NCT06978777
What this study is testing
What is Caffeine (200 mg)?
Caffeine (200 mg) is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for brown adipose tissue (bat) physiology.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- BMI 18.5 to 25 kg/m2
- Able to give informed consent as documented by signature
- Moderate caffeine consumption (1 to 3 cups of coffee per day)
- Increase of EE in response to mild cold of ≥ 5% of REE
You likely can't join if
- Known hypersensitivity or allergy to caffeine
- Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives
- Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, cardiac arrhythmia...
- History of depressive disorder or anxiety disorder
- Smoker / habitual tobacco use
- Habitual excessive alcohol use
See the full eligibility criteria
- BMI 18.5 to 25 kg/m2
- Able to give informed consent as documented by signature
- Moderate caffeine consumption (1 to 3 cups of coffee per day)
- Increase of EE in response to mild cold of ≥ 5% of REE
- Known hypersensitivity or allergy to caffeine
- Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives
- Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, cardiac arrhythmia, hypertension, diabetes mellitus, hyper- or hypothyroidism)
- History of depressive disorder or anxiety disorder
- Smoker / habitual tobacco use
- Habitual excessive alcohol use
- Regular consumption of caffeine containing energy drinks
- Weight change of \>5% within 3 months prior to inclusion
- Systolic blood pressure \>140 mmHg and/or diastolic blood pressure \> 95 mmHg.
- Resting heart rate \>90 bpm
- Hypersensitivity to cold (e.g. Raynaud syndrome)
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.
- Enrolment of the investigator, his/her family members, employees, and other dependent persons
- Enrolment into another study using ionizing radiation within the previous 12 months.
- Pregnancy or lactation
The study team makes the final eligibility decision.
Where it's taking place
- Basel, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Basel, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.