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New treatment option for Depression
Official title Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
ClinicalTrials.gov ID: NCT06976840
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how brain stimulation may work together with antidepressant treatments.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 55
You may be able to join if
- Adults ages 18-55 (\~60% female).
- Diagnosis of Major Depressive Disorder (MDD) with or without comorbid anxiety disorders (e.g., panic disorder) or Axis II disorders.
- Psychotropic-free at enrollment.
You likely can't join if
- being pregnant or breastfeeding;
- diagnosis of psychotic depression, schizophrenia, bipolar disorder, or other Axis I disorders, except for anxiety disorders;
- severe substance use (excluding nicotine) in the last 2 months as determined by using the MINI, a structured interview that uses the Diagnostic and...
- requiring immediate hospitalization;
- epilepsy or conditions requiring an anticonvulsant;
- receiving vagus nerve stimulation, electroconvulsive therapy (ECT), or TMS in the last 2 months;
See the full eligibility criteria
- Adults ages 18-55 (\~60% female).
- Diagnosis of Major Depressive Disorder (MDD) with or without comorbid anxiety disorders (e.g., panic disorder) or Axis II disorders.
- Psychotropic-free at enrollment.
- being pregnant or breastfeeding;
- diagnosis of psychotic depression, schizophrenia, bipolar disorder, or other Axis I disorders, except for anxiety disorders;
- severe substance use (excluding nicotine) in the last 2 months as determined by using the MINI, a structured interview that uses the Diagnostic and Statistical Manual of Mental Disorders;
- requiring immediate hospitalization;
- epilepsy or conditions requiring an anticonvulsant;
- receiving vagus nerve stimulation, electroconvulsive therapy (ECT), or TMS in the last 2 months;
- currently taking or have taken within the last 21 days psychiatric medication or augmenting agents;
- receiving depression-specific psychotherapy;
- actively suicidal or considered a high suicide risk;
- enrolled in another study; or
- MRI/TMS contraindication as determined by the fMRI and TMS screening questionnaires
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 55 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.