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New treatment option for Asthma
Official title Therapeutic Relevance of Abnormal Airway Morphology in Asthma
ClinicalTrials.gov ID: NCT06970080
What this study is testing
What is Inhaled corticosteroid (ICS)?
Inhaled corticosteroid (ICS) is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for asthma.
Also referred to as QVAR, hydrofloroalkaline-beclomethasone dipropionate.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Able and willing to provide written informed consent.
- Able and willing to comply with the study protocol.
- Males and females ≥ 18 years of age.
- Asthma diagnosed by a respiratory physician.
- Airway hyperresponsiveness (defined as methacholine PC20 ≤8mg/mL) and/or bronchodilator reversibility (defined as post-bronchodilator FEV1...
You likely can't join if
- Current smoker, defined as someone having smoked ≥1 cigarette/day (or vape/pipe/cigar/marijuana) for ≥30 days within 12 months prior to screening.
- Pregnant or breastfeeding
- Non-English speaking
- Oral corticosteroids in past 1-month
- Biologic therapy in past 6-months
- Unable to perform proper MDI technique during the screening period
See the full eligibility criteria
- Able and willing to provide written informed consent.
- Able and willing to comply with the study protocol.
- Males and females ≥ 18 years of age.
- Asthma diagnosed by a respiratory physician.
- Airway hyperresponsiveness (defined as methacholine PC20 ≤8mg/mL) and/or bronchodilator reversibility (defined as post-bronchodilator FEV1 improvement ≥200mL and 12%) in the last 6 months
- ACQ ≥1.5 during the screening period.
- Sputum eosinophils ≥3% and/or FeNO ≥35ppb during the screening period.
- Current smoker, defined as someone having smoked ≥1 cigarette/day (or vape/pipe/cigar/marijuana) for ≥30 days within 12 months prior to screening.
- Pregnant or breastfeeding
- Non-English speaking
- Oral corticosteroids in past 1-month
- Biologic therapy in past 6-months
- Unable to perform proper MDI technique during the screening period
- Other pulmonary diseases (e.g., chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension, tuberculosis) requiring treatment within 12 months prior to...
- Unable to undergo MRI. Patient has an implanted mechanically, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators...
The study team makes the final eligibility decision.
Where it's taking place
- Hamilton, Ontario, Canada
- London, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hamilton, Ontario, Canada; London, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.