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New treatment option for Community-acquired Pneumonia
Official title Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
ClinicalTrials.gov ID: NCT06966310
What this study is testing
- What it's testing
- Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and poor outcome. Among invasively mechanically ventilated patients with ARDS and presenting a PaO2/FiO2 ratio (arterial partial pressure of oxygen to inspired fraction of oxygen) of less than 150 mmHg, the prone position significantly reduces mortality and represents standard care (Guérin 2013).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patients admitted to an intensive care unit or intermediate care unit
- Suspicion of community acquired pneumonia (at least one of the 3 criteria): fever, cough, purulent expectoration
- And abnormalities suggestive of pneumonia by chest X-ray or CT-scan
- PaO2/FiO2 ratio \<300 mmHg (or equivalent SpO2/FiO2 i.e. \< 315 mmHg) under a minimum gas flow of 30 L/min.
- Person affiliated to a French social security system or equivalent
You likely can't join if
- Positive SARS-COV2 test within the last 30 days
- Indication for immediate intubation
- Patients for whom a "do not intubate" decision has been made
- Chest trauma or other contraindication to prone position
- Patients with formal indication for non-invasive ventilation: exacerbation of chronic obstructive pulmonary disease, acute cardiogenic pulmonary...
- Pregnant or breastfeeding woman
See the full eligibility criteria
- Adult patients admitted to an intensive care unit or intermediate care unit
- Suspicion of community acquired pneumonia (at least one of the 3 criteria): fever, cough, purulent expectoration
- And abnormalities suggestive of pneumonia by chest X-ray or CT-scan
- PaO2/FiO2 ratio \<300 mmHg (or equivalent SpO2/FiO2 i.e. \< 315 mmHg) under a minimum gas flow of 30 L/min.
- Person affiliated to a French social security system or equivalent
- Informed consent.
- Positive SARS-COV2 test within the last 30 days
- Indication for immediate intubation
- Patients for whom a "do not intubate" decision has been made
- Chest trauma or other contraindication to prone position
- Patients with formal indication for non-invasive ventilation: exacerbation of chronic obstructive pulmonary disease, acute cardiogenic pulmonary oedema.
- Pregnant or breastfeeding woman
- people who are under legal protection measure
- More than 8h awake prone positioning prior to inclusion
- More than 48h since intensive care unit or intermediate care unit admission.
The study team makes the final eligibility decision.
Where it's taking place
- Amiens, France
- Angers, France
- Argenteuil, France
- Belfort, France
- Besançon, France
- Béthune, France
- Blois, France
- Bordeaux, France
- Bourg-en-Bresse, France
- Bourges, France
- Brest, France
- Colombes, France
- Dieppe, France
- Dijon, France
- Dreux, France
- Garche, France
- Grenoble, France
- La Roche-sur-Yon, France
- Le Mans, France
- Lens, France
+ 14 more site(s).
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amiens, France; Angers, France; Argenteuil, France; Belfort, France; Besançon, France; Béthune, France and 28 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.