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New treatment option for Alzheimer Disease
Official title Cervical Lymphatico-Venous Bypass for Treatment of Alzheimer's Disease - Proof of Concept Study (CLyVeB-AD-1 Study)
ClinicalTrials.gov ID: NCT06965062
What this study is testing
- What it's testing
- Alzheimer's disease (AD), one of the most common causes of dementia in Singapore and the developed world, is a neurodegenerative disorder with high socioeconomic impact. Accumulation of neurotoxic proteins (ie.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80
You may be able to join if
- Diagnosis of mild-moderate Alzheimer's disease (based on NIA-AA criteria);
- Mini-Mental State Examination (MMSE) score 10-22;
- Both participants and caregiver are able to understand English or Mandarin
- Ability to provide informed consent or have a legally authorised representative to provide informed consent;
- Good family support for post-treatment care and rehabilitation;
You likely can't join if
- Cognitive decline due to prior infection or autoimmune diseases;
- History of major cerebrovascular events or significant cardiovascular diseases;
- Inability to have the head turned passively by at least 40 degrees;
- Previous neck lymph node surgery or irradiation;
- Active infection or malignancy;
- Any contraindications to surgery or lumbar puncture
See the full eligibility criteria
- Diagnosis of mild-moderate Alzheimer's disease (based on NIA-AA criteria);
- Mini-Mental State Examination (MMSE) score 10-22;
- Both participants and caregiver are able to understand English or Mandarin
- Ability to provide informed consent or have a legally authorised representative to provide informed consent;
- Good family support for post-treatment care and rehabilitation;
- Fit for general anaesthesia/deep sedation and surgery (ASA 1-2; excluding the diagnosis of Alzheimer's Disease).
- Cognitive decline due to prior infection or autoimmune diseases;
- History of major cerebrovascular events or significant cardiovascular diseases;
- Inability to have the head turned passively by at least 40 degrees;
- Previous neck lymph node surgery or irradiation;
- Active infection or malignancy;
- Any contraindications to surgery or lumbar puncture
- Any contraindication to MRI/PET scan (eg. metallic implant that are not MRI-safe, known radiotracer allergy)
- Experimental Alzheimer's Disease treatment within the past 6 months. Current use of monoclonal antibodies treatment (eg. lecanemab/donanemab)
The study team makes the final eligibility decision.
Where it's taking place
- Singapore, Singapore
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Singapore, Singapore. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.