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New treatment option for Herpes Zoster Pain
Official title High-Voltage Long-Duration Pulsed Radiofrequency Combined With Liposomal Bupivacaine Subcutaneous Block for Herpes Zoster-Associated Neuralgia
ClinicalTrials.gov ID: NCT06959147
What this study is testing
What is High-Voltage Long-Duration Pulsed Radiofrequency plus Liposomal Bupivacaine group?
High-Voltage Long-Duration Pulsed Radiofrequency plus Liposomal Bupivacaine group is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for herpes zoster pain.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Research Objectives Background and Significance: Zoster-associated neuralgia (ZAN) refers to neuropathic pain experienced by herpes zoster (HZ) patients before, during, and after rash resolution, characterized by paroxysmal, lightning-like, or knife-like sensations. Postherpetic neuralgia (PHN), a common type of chronic pain, is often accompanied by physical-psychological impairments, social dysfunction, and anxiety-depression.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 85
You may be able to join if
- Patients diagnosed with zoster-associated neuralgia (ZAN) who meet ALL of the following conditions:
- Voluntarily provided written informed consent.
- Inadequate response to pharmacological or other non-surgical therapies OR intolerable drug-related adverse effects.
- Herpes zoster (HZ) lesions involving cranial/cervicocephalic, cervical, thoracic, or lumbar dermatomes.
- Moderate-to-severe pain intensity, defined as a Numerical Rating Scale (NRS) score ≥4 at baseline.
You likely can't join if
- Severe cardiovascular diseases or life-threatening arrhythmias (e.g., heart failure, third-degree atrioventricular block without pacemaker...
- Contraindications to minimally invasive interventions (e.g., coagulation disorders, active infections).
- Allergy to local anesthetics or lipid emulsions; Severe dysfunction of vital organs (cardiac, pulmonary, hepatic, or renal) rendering the patient...
- Severe endocrine disorders or long-term use of corticosteroids/immunosuppressive agents.
- Cognitive impairment or inability to cooperate with treatment protocols.
- Prior history of neuromodulation therapies (e.g., spinal cord stimulation or pulsed radiofrequency (PRF) treatment).
See the full eligibility criteria
- Patients diagnosed with zoster-associated neuralgia (ZAN) who meet ALL of the following conditions:
- Voluntarily provided written informed consent.
- Inadequate response to pharmacological or other non-surgical therapies OR intolerable drug-related adverse effects.
- Herpes zoster (HZ) lesions involving cranial/cervicocephalic, cervical, thoracic, or lumbar dermatomes.
- Moderate-to-severe pain intensity, defined as a Numerical Rating Scale (NRS) score ≥4 at baseline.
- Aged between 40 and 85 years.
- Body weight: Male ≥50 kg; female ≥45 kg.
- Severe cardiovascular diseases or life-threatening arrhythmias (e.g., heart failure, third-degree atrioventricular block without pacemaker implantation).
- Contraindications to minimally invasive interventions (e.g., coagulation disorders, active infections).
- Allergy to local anesthetics or lipid emulsions; Severe dysfunction of vital organs (cardiac, pulmonary, hepatic, or renal) rendering the patient unfit for the procedure.
- Severe endocrine disorders or long-term use of corticosteroids/immunosuppressive agents.
- Cognitive impairment or inability to cooperate with treatment protocols.
- Prior history of neuromodulation therapies (e.g., spinal cord stimulation or pulsed radiofrequency (PRF) treatment).
The study team makes the final eligibility decision.
Where it's taking place
- Zunyi, Guizhou, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Zunyi, Guizhou, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.