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New treatment option for Intraoperative Hypotension
Official title Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
ClinicalTrials.gov ID: NCT06952608
What this study is testing
What is Ciprofol group?
Ciprofol group is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for intraoperative hypotension.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- Patients undergoing elective abdominal surgery under general anesthesia
- Duration of surgery exceeding 2 hours
- Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery)
- Age ≥ 65 years
- ASA classification II-III
You likely can't join if
- History of allergy to opioids, propofol, or ciprofol components.
- Anticipated difficult airway (limited mouth opening, restricted neck movement, or modified Mallampati grade III-IV) or difficult mask ventilation...
- Severe hepatic dysfunction (total bilirubin ≥3.0 mg/dL or AST/ALT ≥2 times the upper limit of normal).
- Severe renal impairment (creatinine clearance ≤30 mL/min).
- Cardiac diseases (AV block higher than first-degree, heart rate \<50 bpm, severe arrhythmias, severe valvular heart disease, heart failure, or...
- Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric illness.
See the full eligibility criteria
- Patients undergoing elective abdominal surgery under general anesthesia
- Duration of surgery exceeding 2 hours
- Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery)
- Age ≥ 65 years
- ASA classification II-III
- Informed consent was obtained from patients or their guardians
- History of allergy to opioids, propofol, or ciprofol components.
- Anticipated difficult airway (limited mouth opening, restricted neck movement, or modified Mallampati grade III-IV) or difficult mask ventilation. Body mass index ≤18 or ≥35 kg/m².
- Severe hepatic dysfunction (total bilirubin ≥3.0 mg/dL or AST/ALT ≥2 times the upper limit of normal).
- Severe renal impairment (creatinine clearance ≤30 mL/min).
- Cardiac diseases (AV block higher than first-degree, heart rate \<50 bpm, severe arrhythmias, severe valvular heart disease, heart failure, or unstable angina on the day of surgery).
- Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric illness.
- Abnormal thyroid-stimulating hormone levels or history of thyroid replacement therapy.
- Unstable asthma or history of asthma.
- Alcohol abuse, drug abuse, chronic opioid dependence, or analgesic use exceeding 3 months.
- Lactating or pregnant women.
The study team makes the final eligibility decision.
Where it's taking place
- Hangzhou, Zhejiang, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hangzhou, Zhejiang, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.