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New treatment option for Hypotension
Official title PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery
ClinicalTrials.gov ID: NCT06952387
What this study is testing
- What it's testing
- High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality. Intraoperative hypotension (IOH), a pervasive clinical phenomenon affecting 40%-90% of surgical cases, Substantial observational evidence links IOH severity/duration to ischemic organ injuries (MINS, AKI) and long-term morbidity.Nevertheless, inherent limitations of observational designs-particularly residual confounding-preclude definitive causal inferences.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 to 90
You may be able to join if
- Aged 65-90 yr;
- Scheduled to undergo elective non-cardiac major surgery under general anesthesia (with an estimated surgery duration of ≥ 2 hours and an anticipated...
- Patients with high cardiovascular risk, meeting at least one of the following conditions:
- History of stroke;
- History of coronary artery disease;
You likely can't join if
- Refuse to participate this trial;
- Inability to communicate in the preoperative period because of coma, profound dementia, or language barrier;
- Severe uncontrolled hypertension before surgery (systolic blood pressure ≥ 180 mmHg, diastolic blood pressure ≥ 110 mmHg);
- Severe hepatic dysfunction (Child-Pugh Class C); or severe renal dysfunction required preoperative dialysis; or American Society of Anesthesiologists...
- Unstable cardiovascular conditions: acute coronary syndrome, decompensated heart failure, severe arrhythmias, severe valvular heart disease;
- Scheduled to undergo neurosurgical procedures, transplantation, vascular surgery;
See the full eligibility criteria
- Aged 65-90 yr;
- Scheduled to undergo elective non-cardiac major surgery under general anesthesia (with an estimated surgery duration of ≥ 2 hours and an anticipated postoperative hospital stay of ≥ 2 days);
- Patients with high cardiovascular risk, meeting at least one of the following conditions:
- History of stroke;
- History of coronary artery disease;
- History of congestive heart failure;
- History of peripheral arterial disease;
- Preoperative brain natriuretic peptide (BNP) ≥ 92 mg/L or N-terminal pro-brain natriuretic peptide (NT-proBNP) ≥ 300 ng/L;
- Preoperative cardiac troponin (cTn) or high-sensitivity cardiac troponin (hs-cTn) \> upper reference limit;
- Hypertension requiring medication treatment;
- Diabetes requiring medication treatment;
- History of chronic kidney disease;
- Continuous smoking for 2 years or more, with interruptions of less than one month before the current hospital admission;
- Hypercholesterolemia;
- History of transient ischemic attack.
- Refuse to participate this trial;
- Inability to communicate in the preoperative period because of coma, profound dementia, or language barrier;
- Severe uncontrolled hypertension before surgery (systolic blood pressure ≥ 180 mmHg, diastolic blood pressure ≥ 110 mmHg);
- Severe hepatic dysfunction (Child-Pugh Class C); or severe renal dysfunction required preoperative dialysis; or American Society of Anesthesiologists (ASA) physical status ≥ V; or expectation lifespan ≤ 24h;
- Unstable cardiovascular conditions: acute coronary syndrome, decompensated heart failure, severe arrhythmias, severe valvular heart disease;
- Scheduled to undergo neurosurgical procedures, transplantation, vascular surgery;
- Urgent surgery;
- Diagnosed with sepsis or sepsis shock before surgery.
- Requiring vasopressor treatment before surgery.
- Unable to finish 24-hour automated blood pressure monitor;
- Current participation in another treatment study.
- Any condition deemed ineligible for participation by clinicians.
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
- Shenzhen, Guangdong, China
- Zhuhai, Guangdong, China
- Xi’an, Shanxi, China
- Hangzhou, Zhejiang, China
Compensation & support
A stipend or compensation may be offered.
Compensation likely.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China; Shenzhen, Guangdong, China; Zhuhai, Guangdong, China; Xi’an, Shanxi, China; Hangzhou, Zhejiang, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.