BridgeMD
New treatment option for Creatine
Official title Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
ClinicalTrials.gov ID: NCT06948149
What this study is testing
- What it's testing
- The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function in older adults with mild cognitive impairment. Previous studies have shown that resistance training improves cognition and brain health in older adults.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 and older
You may be able to join if
- To be eligible to participate in this study participants must:
- be 60 years of age or older,
- live independently in the community,
- have normal or corrected-to-normal vision and hearing,
- read, write, and speak English fluently,
See the full eligibility criteria
- To be eligible to participate in this study participants must:
- be 60 years of age or older,
- live independently in the community,
- have normal or corrected-to-normal vision and hearing,
- read, write, and speak English fluently,
- be right-handed,
- have subjective feelings of memory decline in the past 5 years,
- have MoCA scores 19-25/30 (assessed at baseline session),
- be able to exercise at a moderate pace using resistance training for 60 minutes 3x/week,
- receive clearance from a physician to participate in an exercise program, and 10) receive confirmation from a physician that they meet all criteria to be included in this study. Participants are ineligible if they:
- cannot partake or commit to exercise training 3x/week for 26 weeks or have regularly (\>1x/week) engaged in exercise training over the past 3 months;
- cannot partake or commit to consuming a daily supplement for 26 weeks or consumed nutritional supplements containing creatine monohydrate over the past 3 months;
- have a known allergy to creatine monohydrate or dextrose;
- have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease);
- have pre-existing kidney disease, heart disease, or liver abnormalities;
- have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety);
- are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or
- are ineligible or uncomfortable with MRI (have metal or electronic implants, claustrophobia) or blood sampling.
The study team makes the final eligibility decision.
Where it's taking place
- London, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.