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New treatment option for Kidney Stone
Official title Oxalate and Citrate in Humans - Response to Citrate
ClinicalTrials.gov ID: NCT06944223
What this study is testing
- What it's testing
- This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Stone formers (SF):
- Age 18-70
- History of at least one calcium-based kidney stone Non-stone formers (NSF):
- Age 18-70
- No history of kidney stone
You likely can't join if
- History of primarily uric acid, cysteine, or struvite stones
- History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate
- Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period
- Chronic kidney disease (glomerular filtration rate \<75 milliliters per minute per 1.73 square meters [mL/min/1.73 m²])
- Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce...
See the full eligibility criteria
- Stone formers (SF):
- Age 18-70
- History of at least one calcium-based kidney stone Non-stone formers (NSF):
- Age 18-70
- No history of kidney stone
- 24-hour urine oxalate within laboratory normal range (\<50 mg/day)
- History of primarily uric acid, cysteine, or struvite stones
- History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate
- Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period
- Chronic kidney disease (glomerular filtration rate \<75 milliliters per minute per 1.73 square meters [mL/min/1.73 m²])
- Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.
The study team makes the final eligibility decision.
Where it's taking place
- Chicago, Illinois, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chicago, Illinois, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.