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New treatment option for Wound Healing
Official title Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
ClinicalTrials.gov ID: NCT06941467
What this study is testing
What is Timolol Maleate Solution?
Timolol Maleate Solution is an investigational medicine, given as a treatment applied to the skin, being studied as a potential treatment for wound healing.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years. The majority of the literature has evaluated the use of topical timolol to shorten wound healing time in chronic wounds of non-surgical etiologies.
- Phase 1: an early, usually small safety study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Be scheduled to undergo MMS at 234 East 85th St for a skin cancer that is deemed Mohs
- Appropriate by the Mohs surgery appropriate use criteria
- Have an open surgical wound \ 0.5 cm
- Be ≥18 years of age
- English-speaking
You likely can't join if
- Age less than 18 years of age
- Open surgical wound \> 4 cm
- If tumor clearance cannot be achieved with MMS
- Pregnant women
- Breastfeeding women
- Patients who are taking oral beta-blockers (ie oral timolol, metoprolol, carvedilol, propranolol, atenolol)
See the full eligibility criteria
- Be scheduled to undergo MMS at 234 East 85th St for a skin cancer that is deemed Mohs
- Appropriate by the Mohs surgery appropriate use criteria
- Have an open surgical wound \ 0.5 cm
- Be ≥18 years of age
- English-speaking
- Provide a signed and dated informed consent form
- State willingness to comply with all study procedures
- Age less than 18 years of age
- Open surgical wound \> 4 cm
- If tumor clearance cannot be achieved with MMS
- Pregnant women
- Breastfeeding women
- Patients who are taking oral beta-blockers (ie oral timolol, metoprolol, carvedilol, propranolol, atenolol)
- Patients who are currently taking any of the following medications: clonidine, digoxin, methyldopa, quinidine, fluoxetine and paroxetine, bupropion
- Patient currently taking a calcium channel blocker AND has pre-existing heart failure as defined by a reduced ejection fraction
- Patients with pre-existing hypotension
- Pre-existing diagnosis of sinus bradycardia
- Pre-existing diagnosis of second or third degree atrioventricular block
- Congestive heart failure
- Pre-existing diagnosis of severe asthma
- Pre-existing diagnosis of chronic obstructive pulmonary disease
- Any known hypersensitivity to 0.5% timolol solution
- Patients who have a wound where primary closure is feasible and desired by the patient
- Defect size \<0.5 cm
- Prior sensitivity or known allergy to timolol
The study team makes the final eligibility decision.
Where it's taking place
- New York, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include New York, New York, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.