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Official title Neural and Psychiatric Consequences of Cannabis Use in Adolescents
ClinicalTrials.gov ID: NCT06941298
What this study is testing
- What it's testing
- The goal of this study is to investigate the effects of cannabis on brain function among adolescents with depression.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 14 to 20. Healthy volunteers may be eligible.
You may be able to join if
- at baseline.
- Cannabis users: To capture a wide range of cannabis use frequency, meeting DSM-5 criteria for cannabis use disorder will not be required. However, in...
- Depression: Similarly, to capture a wide range of depression illness severity, we will allow participants with subthreshold depression, defined as a...
You likely can't join if
- . All participants:
- Psychotropic medication free for more than 1 month (or more than three months for medications with a long half-life such as fluoxetine) prior to...
- MRI contraindications such as claustrophobia, metallic ink tattoos, orthodontic braces, or pacemakers
- Positive pregnancy tests
- Neurological illnesses and medical conditions such as unique pain syndromes (e.g. multiple sclerosis, rheumatoid arthritis)
- Estimated full-scale IQ \<=80 to ensure that participants have the ability to understand the study
See the full eligibility criteria
- at baseline.
- Cannabis users: To capture a wide range of cannabis use frequency, meeting DSM-5 criteria for cannabis use disorder will not be required. However, in order to ensure sufficient exposure, we will require majority of...
- Depression: Similarly, to capture a wide range of depression illness severity, we will allow participants with subthreshold depression, defined as a raw severity score of \>=30 on the Children's Depression Rating...
- . All participants:
- Psychotropic medication free for more than 1 month (or more than three months for medications with a long half-life such as fluoxetine) prior to study enrollment. We have successfully enrolled hundreds of psychotropic...
- MRI contraindications such as claustrophobia, metallic ink tattoos, orthodontic braces, or pacemakers
- Positive pregnancy tests
- Neurological illnesses and medical conditions such as unique pain syndromes (e.g. multiple sclerosis, rheumatoid arthritis)
- Estimated full-scale IQ \<=80 to ensure that participants have the ability to understand the study
- Current SUD other than cannabis or nicotine. Excluding nicotine use will limit generalization of our findings and impact feasibility. Similarly, alcohol use will be allowed as long as it is not hazardous and does not...
- Certified for or self-reported medical cannabis use, or intent to become certified, current stimulant use (methamphetamine or cocaine) by self-report or urine toxicology. Adderall and Vyvanse for ADHD will be allowed as...
- Oral contraceptives will be allowed and controlled for in order to maximize recruitment of older adolescents. Depressed THC non-users:
- DSM-5 diagnoses of bipolar disorder, psychotic disorders, autism spectrum disorders, and all non-cannabis substance-related disorders will be exclusionary. However, anxiety disorders, obsessive-compulsive disorder...
- Self-injurious acts (e.g. cutting) and suicidal ideations (SI) without a specific plan (defined as passive SI) are common in adolescent depression and will be allowed. However, if SI constitutes an imminent risk to self...
The study team makes the final eligibility decision.
Where it's taking place
- Miami, Florida, United States
- Orangeburg, New York, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 14 years to 20 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Miami, Florida, United States; Orangeburg, New York, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.