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New treatment option for Gut-Brain Disorders
Official title Cognitive-behavioral Therapy for the Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
ClinicalTrials.gov ID: NCT06939465
What this study is testing
- What it's testing
- Gastroesophageal reflux disease (GERD) is a challenging gastrointestinal disorder, and proton pump inhibitors (PPIs) are typically the first line of treatment. However, up to 40% of GERD patients experience little to no relief or only partial relief of their symptoms after receiving PPI therapy.
- This is a blinded study.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Age between 18 and 75 years, with clear consciousness and willingness to sign the informed consent form.
- people with chronic esophageal symptoms related to disorders of the brain-gut axis communication (such as heartburn, acid reflux, sensation of a...
You likely can't join if
- Esophageal strictures, or history of surgery on the esophagus, gastrointestinal tract, or throat.
- Structural esophageal diseases (such as diverticula, esophageal rings, etc.), infectious esophagitis, erosive esophagitis, eosinophilic esophagitis.
- Non-erosive gastroesophageal reflux disease or significant esophageal motility disorders.
- History of or current diagnosis of malignancies in the esophagus, gastrointestinal tract, or other organs.
- Significant endocrine or rheumatic immune diseases that may affect gastrointestinal motility.
- Continuous use of medications that may affect esophageal motility within the past month (such as anticholinergics, opioid-like agents, nitrates...
See the full eligibility criteria
- Age between 18 and 75 years, with clear consciousness and willingness to sign the informed consent form.
- people with chronic esophageal symptoms related to disorders of the brain-gut axis communication (such as heartburn, acid reflux, sensation of a foreign body in the throat, difficulty swallowing, and chest pain or...
- Esophageal strictures, or history of surgery on the esophagus, gastrointestinal tract, or throat.
- Structural esophageal diseases (such as diverticula, esophageal rings, etc.), infectious esophagitis, erosive esophagitis, eosinophilic esophagitis.
- Non-erosive gastroesophageal reflux disease or significant esophageal motility disorders.
- History of or current diagnosis of malignancies in the esophagus, gastrointestinal tract, or other organs.
- Significant endocrine or rheumatic immune diseases that may affect gastrointestinal motility.
- Continuous use of medications that may affect esophageal motility within the past month (such as anticholinergics, opioid-like agents, nitrates, calcium channel blockers, etc.).
- Use of or currently taking antidepressants, selective serotonin reuptake inhibitors, or other psychotropic medications within the past three months.
- Pregnant or breastfeeding women.
- Individuals with mental illness or those who are unable to cooperate.
- Known allergy to tricyclic antidepressants.
- Known allergy to selective serotonin reuptake inhibitors.
- Known allergy to any component of proton pump inhibitors.
The study team makes the final eligibility decision.
Where it's taking place
- Hualien City, Taiwan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hualien City, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.