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New treatment option for Cardiac Arrest (CA)
Official title The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
ClinicalTrials.gov ID: NCT06939335
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age: Adults aged 18 years and older.
- Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.
- CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.
- Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.
You likely can't join if
- Cardiac arrest in patient younger than 18 years of age.
- Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.
- Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.
- Pregnancy.
- Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than...
- Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.
See the full eligibility criteria
- Age: Adults aged 18 years and older.
- Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.
- CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.
- Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.
- Cardiac arrest in patient younger than 18 years of age.
- Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.
- Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.
- Pregnancy.
- Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded.
- Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.
- Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded.
- Enrolment in Other Studies: Patients currently enrolled in another treatment clinical trial that could interfere with the outcomes of this study.
The study team makes the final eligibility decision.
Where it's taking place
- Ostend, West-Flandres, Belgium
- Aalst, Belgium
- Geraardsbergen, Belgium
- Ghent, Belgium
- Knokke, Belgium
- Besançon, France
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ostend, West-Flandres, Belgium; Aalst, Belgium; Geraardsbergen, Belgium; Ghent, Belgium; Knokke, Belgium; Besançon, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.